Explain Why Does Wheat Cause Gut Inflammation
Does wheat cause gut inflammation?
By Liji Thomas, MD
Inflammation is a pathway triggered by the exposure of the innate immune system to injury, infections or noxious stimuli. Sustained exposure or abnormal continuous activation of the immune cells to such stimuli can lead to chronic inflammation. Such a condition is characterized by elevated levels of proinflammatory serum markers including the interleukins, acute phase proteins and interferons. The reasons for such prolonged inflammatory responses are unclear, but may be due to a genetic predisposition, stress (physical and/or psychological), and dietary imbalances in the form of excessive content of certain simple carbohydrates and proinflammatory lipids. One such component arising from …show more content…
Different domains of the gliadin protein molecule may be responsible for the various aspects of celiac disease, including cytotoxicity, gut permeability and mucosal inflammation. This process damages the intestinal barrier, which is responsible for the absorption of nutrients as well as for confining toxins within the gut lumen. Such damage allows increased contact and interaction between these molecules and the cells of the innate and adaptive immune system within the lamina propria of the intestinal mucosa, via transcytosis. In addition, epithelial microfold cells actively transport antigens in food as well as on gut bacteria into the immune system to promote either an immune reaction or immune tolerance. These cells do not normally allow large peptides and proteins to pass, but a breakdown of this barrier causes a higher rate of antigen passage and reaction with the immune …show more content…
The explanation may be that the HLA type affects some resident gut bacteria, which in turn worsens the pathological changes that precipitate overt celiac disease by allowing proinflammatory bacteria to proliferate at the expense of other species, which encourage anti-inflammatory reactions. The eventual outcome of the weakening of the mucosal barrier is the manifestation of gluten intolerance in these
By Liji Thomas, MD
Inflammation is a pathway triggered by the exposure of the innate immune system to injury, infections or noxious stimuli. Sustained exposure or abnormal continuous activation of the immune cells to such stimuli can lead to chronic inflammation. Such a condition is characterized by elevated levels of proinflammatory serum markers including the interleukins, acute phase proteins and interferons. The reasons for such prolonged inflammatory responses are unclear, but may be due to a genetic predisposition, stress (physical and/or psychological), and dietary imbalances in the form of excessive content of certain simple carbohydrates and proinflammatory lipids. One such component arising from …show more content…
Different domains of the gliadin protein molecule may be responsible for the various aspects of celiac disease, including cytotoxicity, gut permeability and mucosal inflammation. This process damages the intestinal barrier, which is responsible for the absorption of nutrients as well as for confining toxins within the gut lumen. Such damage allows increased contact and interaction between these molecules and the cells of the innate and adaptive immune system within the lamina propria of the intestinal mucosa, via transcytosis. In addition, epithelial microfold cells actively transport antigens in food as well as on gut bacteria into the immune system to promote either an immune reaction or immune tolerance. These cells do not normally allow large peptides and proteins to pass, but a breakdown of this barrier causes a higher rate of antigen passage and reaction with the immune …show more content…
The explanation may be that the HLA type affects some resident gut bacteria, which in turn worsens the pathological changes that precipitate overt celiac disease by allowing proinflammatory bacteria to proliferate at the expense of other species, which encourage anti-inflammatory reactions. The eventual outcome of the weakening of the mucosal barrier is the manifestation of gluten intolerance in these