Expt 4 formal report
Purification of Acetanilide by Recrystallization Method
Dupaya, Julian Victor M. Estacio, Jerwin Caesar A.
Farnacio, Rebecca Ruth Gabito, Jose Luis F. Gallo, Cian Carlo M. Galvez, Joshua M.
Group no.4, 2D-Medical Technology, Faculty of Pharmacy, University of Santo Tomas
ABSTRACT
Recrystallization is a method for purifying solid organic compounds. The process is dissolving the solid to be purified in a hot solvent and cooling the solution slowly, this allows impurities with different solubility to separate from the solution in each step. The objective of the experiment was to synthesize acetanilide by the acetylation of aniline and to purify crude acetanilide product by recrystallization. The group determined water as the recrystallizing solvent. The group performed acetylation of aniline and acetic anhydride for the formation of crude acetanilide. The recrystallizing solvent dissolved the crude acetanilide and was heated in a water bath, after heating, the solution was cooled in an ice bath causing crystals to form. The percent recovery was computed to be 38.49% while the percent yield was computed to be 34.46%.
INTRODUCTION
Compounds that are obtained from natural sources or from reaction of chemicals almost always contain impurities. The impurities may include some combination of insoluble, soluble, and colored impurities. To obtain a pure compound these impurities must be removed. Recrystallization is a method in which two crystallization processes was performed. It is referred to the second crystallization. (Pavia, Lampman, Kriz, & Engel, 1999) Recrystallization is a widely used purification process that removes these impurities from the compound. In performing recrystallization, solubility tests will be used to find a suitable recrystallization solvent for the compound. To determine which the most suitable recrystallizing solvent is, the compound should have a high solubility in the hot solvent and a low solubility in the cold
Dupaya, Julian Victor M. Estacio, Jerwin Caesar A.
Farnacio, Rebecca Ruth Gabito, Jose Luis F. Gallo, Cian Carlo M. Galvez, Joshua M.
Group no.4, 2D-Medical Technology, Faculty of Pharmacy, University of Santo Tomas
ABSTRACT
Recrystallization is a method for purifying solid organic compounds. The process is dissolving the solid to be purified in a hot solvent and cooling the solution slowly, this allows impurities with different solubility to separate from the solution in each step. The objective of the experiment was to synthesize acetanilide by the acetylation of aniline and to purify crude acetanilide product by recrystallization. The group determined water as the recrystallizing solvent. The group performed acetylation of aniline and acetic anhydride for the formation of crude acetanilide. The recrystallizing solvent dissolved the crude acetanilide and was heated in a water bath, after heating, the solution was cooled in an ice bath causing crystals to form. The percent recovery was computed to be 38.49% while the percent yield was computed to be 34.46%.
INTRODUCTION
Compounds that are obtained from natural sources or from reaction of chemicals almost always contain impurities. The impurities may include some combination of insoluble, soluble, and colored impurities. To obtain a pure compound these impurities must be removed. Recrystallization is a method in which two crystallization processes was performed. It is referred to the second crystallization. (Pavia, Lampman, Kriz, & Engel, 1999) Recrystallization is a widely used purification process that removes these impurities from the compound. In performing recrystallization, solubility tests will be used to find a suitable recrystallization solvent for the compound. To determine which the most suitable recrystallizing solvent is, the compound should have a high solubility in the hot solvent and a low solubility in the cold
References: Lehman, J. (2009). Operational Organic Chemistry: A problem solving approach to laboratory course. New Jersey, USA.. Pearson Education Inc., Pg. 692, 705-706 (n.a.) (2012, 09). Recrystallization. StudyMode.com. Retrieved September 9, 2014, from http://www.studymode.com/essays/Recrystallization-1090869.html Bayquen, A., Sarile, A. et al. (2014). Laboratory Manual In Organic Chemistry. Quezon City, Philippines. C & E Publishing Inc. Pg. 47-48 (n.a.) (n.d.) Recrystallization. Retrived September 9, 2014 from http://www.wiredchemist.com/chemistry/instructional/laboratory-tutorials/recrystallization Wigal, C. (n.d.) Purifying Acetanilide by Recrystallization. Retrieved September 9, 2014 from http://www.cerlabs.com/experiments/10875040703X.pdf (n.a.) (n.d.) Acetanilide Retrieved September 10, 2014 from http://www.chemicalland21.com/lifescience/phar/ACETANILIDE.htm (n.a.) (n.d.) Limiting Reactants, Theoretical Yield and Percent Yield. Retrieved September 10, 2014 from https://chemistry.twu.edu/tutorial/LimReactantSum.html