Fragile X Syndrome Research Papers
Fragile x syndrome- is a genetic condition that cause alot of growing problems including learning disabilities and cognitive impairment. Usually, males are more affected by this disorder than females.
In 1943, Martin and Bell showed that a particular form of mental retardation was X-linked.However, due to genetic anticipation and X-inactivation in females, the inheritance of Fragile X syndrome does not follow the usual pattern of X-linked dominant inheritance and some scholars have suggested discontinuing labeling X-linked disorders as dominant or recessive.While there is currently no cure for Fragile X syndrome (FXS), there are many areas of treatment and intervention that can improve the lives of affected individuals and their families. …show more content…
Studies have been undertaken both in the “special needs” population and the general population. The agreed upon prevalence of FXS in males is approximately 1 in 3,600 to 4,000 and in females is approximately 1 in 4,000 to 6,000.
The reason it is lower in females is that, while all males with an FMR1 full mutation will have Fragile X syndrome, some females with an FMR1 full mutation will not have behavioral, cognitive or physical features of FXS.
Fragile X Syndrome (FXS) is caused by the expansion or lengthening of the FMR1 gene on the X chromosome, known as a gene mutation. The X chromosome is one of two sex determining chromosomes. When the gene lengthens it switches off production of a protein that is involved in brain development and other functions
From what I know on my own is that Fragile x is a gene mutation that affects mental issues rather than physical. It affects males more than females because the females FMR1 full mutation will not have the behavior or physical features of fragile x syndrome. FMR1 is Fragile X Mental Retardation 1
https://ghr.nlm.nih.gov/condition/fragile-x-syndrome
In 1943, Martin and Bell showed that a particular form of mental retardation was X-linked.However, due to genetic anticipation and X-inactivation in females, the inheritance of Fragile X syndrome does not follow the usual pattern of X-linked dominant inheritance and some scholars have suggested discontinuing labeling X-linked disorders as dominant or recessive.While there is currently no cure for Fragile X syndrome (FXS), there are many areas of treatment and intervention that can improve the lives of affected individuals and their families. …show more content…
Studies have been undertaken both in the “special needs” population and the general population. The agreed upon prevalence of FXS in males is approximately 1 in 3,600 to 4,000 and in females is approximately 1 in 4,000 to 6,000.
The reason it is lower in females is that, while all males with an FMR1 full mutation will have Fragile X syndrome, some females with an FMR1 full mutation will not have behavioral, cognitive or physical features of FXS.
Fragile X Syndrome (FXS) is caused by the expansion or lengthening of the FMR1 gene on the X chromosome, known as a gene mutation. The X chromosome is one of two sex determining chromosomes. When the gene lengthens it switches off production of a protein that is involved in brain development and other functions
From what I know on my own is that Fragile x is a gene mutation that affects mental issues rather than physical. It affects males more than females because the females FMR1 full mutation will not have the behavior or physical features of fragile x syndrome. FMR1 is Fragile X Mental Retardation 1
https://ghr.nlm.nih.gov/condition/fragile-x-syndrome