Goodpasture Syndrome Case Studies
Goodpasture's syndrome (GS) is a rare disease, identified by Dr. Ernest Goodpasture in 1919
He described the syndrome during the influenza pandemic of 1919 when he reported on a patient who died from bleeding in the lungs and kidney failure.
The incidence of Goodpasture is estimated to 1 case per million per year. This disease occurs more commonly in white people than in black people and is widespread in men than in women.
Goodpasture syndrome is a pulmonary-renal syndrome, which is a group of acute illnesses involving the kidneys and lungs.
Goodpasture syndrome includes all the following conditions: -glomerulonephritis—inflammation of the glomeruli, which are tiny clusters of looping blood vessels in the kidneys that help filter wastes and extra water from the blood …show more content…
Blood test: A blood test can show presence of anti-GBM antibodies.
Biopsy test can show crescent-shaped changes in the glomeruli and lines of antibodies attached to the GBM.
Chest x-ray will reveal patchy parenchymal consolidations, which are usually bilateral, symmetric perihilar, and bibasilar.
Goodpasture syndrome treatment includes: immunosuppressive medications, such as cyclophosphamide, to keep the immune system from making antibodies corticosteroid medications to suppress the body’s autoimmune response plasmapheresis—a procedure that uses a machine to remove blood from the body, separate certain cells from the plasma, and return just the cells to the person’s body; the anti-GBM antibodies remain in the plasma and are not returned to the person’s body.
Goodpasture Syndrome is often rapidly evolving and can be fatal if not diagnosed and treated promptly. The prognosis is favorable when treatment begins before the onset of respiratory or renal insufficiency. Hemoptysis may be a sign of good prognosis because it allows for earlier detection of the
He described the syndrome during the influenza pandemic of 1919 when he reported on a patient who died from bleeding in the lungs and kidney failure.
The incidence of Goodpasture is estimated to 1 case per million per year. This disease occurs more commonly in white people than in black people and is widespread in men than in women.
Goodpasture syndrome is a pulmonary-renal syndrome, which is a group of acute illnesses involving the kidneys and lungs.
Goodpasture syndrome includes all the following conditions: -glomerulonephritis—inflammation of the glomeruli, which are tiny clusters of looping blood vessels in the kidneys that help filter wastes and extra water from the blood …show more content…
Blood test: A blood test can show presence of anti-GBM antibodies.
Biopsy test can show crescent-shaped changes in the glomeruli and lines of antibodies attached to the GBM.
Chest x-ray will reveal patchy parenchymal consolidations, which are usually bilateral, symmetric perihilar, and bibasilar.
Goodpasture syndrome treatment includes: immunosuppressive medications, such as cyclophosphamide, to keep the immune system from making antibodies corticosteroid medications to suppress the body’s autoimmune response plasmapheresis—a procedure that uses a machine to remove blood from the body, separate certain cells from the plasma, and return just the cells to the person’s body; the anti-GBM antibodies remain in the plasma and are not returned to the person’s body.
Goodpasture Syndrome is often rapidly evolving and can be fatal if not diagnosed and treated promptly. The prognosis is favorable when treatment begins before the onset of respiratory or renal insufficiency. Hemoptysis may be a sign of good prognosis because it allows for earlier detection of the