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Vitamin D Supplementation and Cardiovascular Disease Risk
Erin D. Michos and Roger S. Blumenthal
Circulation. 2007;115:827-828 doi: 10.1161/CIRCULATIONAHA.106.686238
Circulation is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231
Copyright © 2007 American Heart Association, Inc. All rights reserved.
Print ISSN: 0009-7322. Online ISSN: 1524-4539
The online version of this article, along with updated information and services, is located on the
World Wide Web at: http://circ.ahajournals.org/content/115/7/827 Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial
Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document.
Reprints: Information about reprints can be found online at: http://www.lww.com/reprints Subscriptions: Information about subscribing to Circulation is online at: http://circ.ahajournals.org//subscriptions/ Downloaded from http://circ.ahajournals.org/ by guest on November 14, 2013
Editorial
Vitamin D Supplementation and Cardiovascular
Disease Risk
Erin D. Michos, MD; Roger S. Blumenthal, MD
M
any studies,1,2 but not all, have shown that low bone density is associated with increased cardiovascular disease (CVD) risk. Vitamin D deficiency is common in the elderly and is associated with osteoporosis; however, the association of endogenous 25-OH vitamin D
(25-OH D) levels with CVD events is controversial.3,4 CVD rates are higher during winter seasons and at increased geographic latitudes where average serum vitamin D levels are lowest.5 Low 25-OH D levels have been found in
Erin D. Michos and Roger S. Blumenthal
Circulation. 2007;115:827-828 doi: 10.1161/CIRCULATIONAHA.106.686238
Circulation is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231
Copyright © 2007 American Heart Association, Inc. All rights reserved.
Print ISSN: 0009-7322. Online ISSN: 1524-4539
The online version of this article, along with updated information and services, is located on the
World Wide Web at: http://circ.ahajournals.org/content/115/7/827 Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial
Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document.
Reprints: Information about reprints can be found online at: http://www.lww.com/reprints Subscriptions: Information about subscribing to Circulation is online at: http://circ.ahajournals.org//subscriptions/ Downloaded from http://circ.ahajournals.org/ by guest on November 14, 2013
Editorial
Vitamin D Supplementation and Cardiovascular
Disease Risk
Erin D. Michos, MD; Roger S. Blumenthal, MD
M
any studies,1,2 but not all, have shown that low bone density is associated with increased cardiovascular disease (CVD) risk. Vitamin D deficiency is common in the elderly and is associated with osteoporosis; however, the association of endogenous 25-OH vitamin D
(25-OH D) levels with CVD events is controversial.3,4 CVD rates are higher during winter seasons and at increased geographic latitudes where average serum vitamin D levels are lowest.5 Low 25-OH D levels have been found in
References: and risk of coronary heart disease: the Framingham study. Am J Epidemiol. 2004;159:589 –595. levels: a community-based study. Int J Epidemiol. 1990;19:559 –563. of congestive heart failure? J Am Coll Cardiol. 2003;41:105–112. coronary calcification. Circulation. 1997;96:1755–1760. QJM. 2002;95:787–796. of vitamin D. J Clin Endocrinol Metab. 2003;88:4623– 4632. historical cohort study. J Am Soc Nephrol. 2005;16:1115–1125. Initiative Investigators. Calcium/vitamin D supplementation and cardiovascular events. Circulation. 2007;115:846 – 854. 16. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999;69:842– 856. 19. Grimes DS. Are statins analogues of vitamin D? Lancet. 2006;368: 83– 86. Dis. 2005;15:S5-97–S-101. Downloaded from http://circ.ahajournals.org/ by guest on November 14, 2013 Ⅲ