Lactic Acidosis
Lactic acidosis
URL of this page: http://www.nlm.nih.gov/medlineplus/ency/article/000391.htm
Lactic acidosis is when lactic acidlactic acid builds ups in the blood stream faster than it can be removed. Lactic acid is produced when oxygen levels in the body drop.
Causes
Causes
The most common cause is intense exercise. However, it can also be caused by certain diseases, such as sepsis, respiratory failure, cardiac failure, AIDS, cancer, and kidney failure.
Metformin, a common medicine used to treat diabetes, can also cause lactic acidosis. People taking this medicine should have their electrolyte levels checked 1 - 2 weeks after starting it.
Symptoms
Symptoms
• Nausea • Weakness
Lactic Acidosis Update for Critical Care Clinicians
Abstract
Abstract. Lactic acidosis is a broad-anion gap metabolic acidosis caused by lactic acid overproduction or underutilization. The quantitative dimensions of these two mechanisms commonly differ by 1 order of magnitude. Overproduction of lactic acid, also termed type A lactic acidosis, occurs when the body must regenerate ATP without oxygen (tissue hypoxia). Circulatory, pulmonary, or hemoglobin transfer disorders are commonly responsible. Overproduction of lactate also occurs with cyanide poisoning or certain malignancies. Underutilization involves removal of lactic acid by oxidation or conversion to glucose. Liver disease, inhibition of gluconeogenesis, pyruvate dehydrogenase (thiamine) deficiency, and uncoupling of oxidative phosphorylation are the most common causes. The kidneys also contribute to lactate removal. Concerns have been raised regarding the role of metformin in the production of lactic acidosis, on the basis of individual case reports. The risk appears to be considerably less than with phenformin and involves patients with underlying severe renal and cardiac dysfunction. Drugs used to treat lactic acidosis can aggravate the condition. NaHCO3 increases lactate
URL of this page: http://www.nlm.nih.gov/medlineplus/ency/article/000391.htm
Lactic acidosis is when lactic acidlactic acid builds ups in the blood stream faster than it can be removed. Lactic acid is produced when oxygen levels in the body drop.
Causes
Causes
The most common cause is intense exercise. However, it can also be caused by certain diseases, such as sepsis, respiratory failure, cardiac failure, AIDS, cancer, and kidney failure.
Metformin, a common medicine used to treat diabetes, can also cause lactic acidosis. People taking this medicine should have their electrolyte levels checked 1 - 2 weeks after starting it.
Symptoms
Symptoms
• Nausea • Weakness
Lactic Acidosis Update for Critical Care Clinicians
Abstract
Abstract. Lactic acidosis is a broad-anion gap metabolic acidosis caused by lactic acid overproduction or underutilization. The quantitative dimensions of these two mechanisms commonly differ by 1 order of magnitude. Overproduction of lactic acid, also termed type A lactic acidosis, occurs when the body must regenerate ATP without oxygen (tissue hypoxia). Circulatory, pulmonary, or hemoglobin transfer disorders are commonly responsible. Overproduction of lactate also occurs with cyanide poisoning or certain malignancies. Underutilization involves removal of lactic acid by oxidation or conversion to glucose. Liver disease, inhibition of gluconeogenesis, pyruvate dehydrogenase (thiamine) deficiency, and uncoupling of oxidative phosphorylation are the most common causes. The kidneys also contribute to lactate removal. Concerns have been raised regarding the role of metformin in the production of lactic acidosis, on the basis of individual case reports. The risk appears to be considerably less than with phenformin and involves patients with underlying severe renal and cardiac dysfunction. Drugs used to treat lactic acidosis can aggravate the condition. NaHCO3 increases lactate