Macular Degeneration Essay
ABC Transporters: Juvenile Macular Degeneration (JMD)
The ATP-Binding Cassette (ABC) also known as ATP-driven membrane pump is a superfamily of protein with a subfamily that contains a well-maintained ATP binding and several transmembrane domains (Devlin, 2011). Each member of the superfamily oversees the process of catalyzation dependent of ATP transporter from a wide diversity of substances and mediums present in different tissues in the body (Devlin, 2011). In addition, they are intricate in the transport of other substances, which include toxins from kidneys, Gastrointestinal (GI) tract, and liver (Leonard, 2003). Furthermore, ABC transporters are responsible for the filtration of toxins from the placenta, brain, and testis, and any abnormality or mutation in the genes encoding …show more content…
In fact, JMD encompasses several inherited and rare diseases related to a wide variety of eye defects (Kiertan, 2015) that affect children and young adults (Web MD, 2016). For instance, the most common of all is Stargardt’s disease, which results in a 20/200 vision, defined as legal blindness (Kiertan, 2015). Furthermore, all the diseases within JMD have similar symptoms where the symptoms do not always affect both eyes, and the side vision is not always affected (Kiertan, 2015). In essence, the affected organ in JMD is the macula which is part of the retina and is the tissue in the eye that reacts to light and is responsible for central vision (Kiertan, 2015). In other words, it is the part of the eye that helps you read small prints like the little letters at the end of a promotional offer and helps you read street signs (Kiertan, 2015). In patients with JMD, the prognosis is poor, and there is no treatment to slow down the progression of the
The ATP-Binding Cassette (ABC) also known as ATP-driven membrane pump is a superfamily of protein with a subfamily that contains a well-maintained ATP binding and several transmembrane domains (Devlin, 2011). Each member of the superfamily oversees the process of catalyzation dependent of ATP transporter from a wide diversity of substances and mediums present in different tissues in the body (Devlin, 2011). In addition, they are intricate in the transport of other substances, which include toxins from kidneys, Gastrointestinal (GI) tract, and liver (Leonard, 2003). Furthermore, ABC transporters are responsible for the filtration of toxins from the placenta, brain, and testis, and any abnormality or mutation in the genes encoding …show more content…
In fact, JMD encompasses several inherited and rare diseases related to a wide variety of eye defects (Kiertan, 2015) that affect children and young adults (Web MD, 2016). For instance, the most common of all is Stargardt’s disease, which results in a 20/200 vision, defined as legal blindness (Kiertan, 2015). Furthermore, all the diseases within JMD have similar symptoms where the symptoms do not always affect both eyes, and the side vision is not always affected (Kiertan, 2015). In essence, the affected organ in JMD is the macula which is part of the retina and is the tissue in the eye that reacts to light and is responsible for central vision (Kiertan, 2015). In other words, it is the part of the eye that helps you read small prints like the little letters at the end of a promotional offer and helps you read street signs (Kiertan, 2015). In patients with JMD, the prognosis is poor, and there is no treatment to slow down the progression of the