Major Histocompatibility Complex
The major histocompatibility complex and its functions
Answer:
The Major Histocompatibility Complex: It is group of genes which code for the proteins which are present on the surfaces of cells and they help the immune system in recognizing foreign substances. The Major HIstocomplex is actually a set of proteins present on cell surface which are important to the acquired immune system . This complex recognizes the foreign molecules in vertebrates, which determines the Histocompability. The Major Histocompatibility Complex (MHC) is present in all vertebrates. There are two major types of this complex i.e.
• MHC Class I (which present foreign peptides cytotoxic T cells)
• MHC Class II (which present foreign peptides to helper T cells) …show more content…
In extended these peptide are represented an extended form (not folded). The strategy of these molecules is to bind peptide fragments on their constant region (the backbone region of the peptide). They do not recognize the variable part or the R groups of the amino acids but they only recognize the constant parts of the amino acid backbone. In extended conformation, the terminal amino group binds to an invariant pocket at one end of the groove and its terminal carboxyl group binds to an invariant pocket at the other end of the groove. These pockets recognize peptide backbone features common to all peptides. In this way MHC molecule is able to grape bind and display proteins of peptide fragments which may be very diverse. So, these MHC molecules are basically displaying peptide fragments of the cell on there surface. These peptide fragments can be from two different sources i.e. either they are product of normal proteins within our cells that get degraded by normal process or they can be foreign in origin. MHC molecules allow lymphocytes to detect microphages that have ingested infectious microorganism so MHC molecules are very important. When a macrophage engulfs the microorganism, it partially digest it and peptide fragments of microbe are appeared on the its surface which forms bond with MHC molecule. T lymphocyte shows response to it, T lymphocyte binds to foreign molecule attached to MHC molecule and stimulates an immune
Answer:
The Major Histocompatibility Complex: It is group of genes which code for the proteins which are present on the surfaces of cells and they help the immune system in recognizing foreign substances. The Major HIstocomplex is actually a set of proteins present on cell surface which are important to the acquired immune system . This complex recognizes the foreign molecules in vertebrates, which determines the Histocompability. The Major Histocompatibility Complex (MHC) is present in all vertebrates. There are two major types of this complex i.e.
• MHC Class I (which present foreign peptides cytotoxic T cells)
• MHC Class II (which present foreign peptides to helper T cells) …show more content…
In extended these peptide are represented an extended form (not folded). The strategy of these molecules is to bind peptide fragments on their constant region (the backbone region of the peptide). They do not recognize the variable part or the R groups of the amino acids but they only recognize the constant parts of the amino acid backbone. In extended conformation, the terminal amino group binds to an invariant pocket at one end of the groove and its terminal carboxyl group binds to an invariant pocket at the other end of the groove. These pockets recognize peptide backbone features common to all peptides. In this way MHC molecule is able to grape bind and display proteins of peptide fragments which may be very diverse. So, these MHC molecules are basically displaying peptide fragments of the cell on there surface. These peptide fragments can be from two different sources i.e. either they are product of normal proteins within our cells that get degraded by normal process or they can be foreign in origin. MHC molecules allow lymphocytes to detect microphages that have ingested infectious microorganism so MHC molecules are very important. When a macrophage engulfs the microorganism, it partially digest it and peptide fragments of microbe are appeared on the its surface which forms bond with MHC molecule. T lymphocyte shows response to it, T lymphocyte binds to foreign molecule attached to MHC molecule and stimulates an immune