Mbbs
A
B
Pgc
Ppt
GFR = Kf (net filtration pressure) = Kf (Pgc - Pbc - *gc ) Pgc *gc af ~~~~~~~~~~~~~~~ef
Pbc
Kf - water permeability - total surface area for filtration GFR= 120 ml/min ? liters/day Mesangial cells ECF , (TBW, 42 liters)
PeeSS RBF?
Arthur Vander
When renal sympathetic nerve is stimulated, the glomerular capillary hydrostatic pressure A. will increase B. will decrease C. may or may not decrease D. I don’t like Starling
D. this question stimulates my para-sympathetic and makes me want to pee
Net Filtration Pressure
GFR
gender body size age
ml/min per 1.73m2
microAlbuminuria;
30 - 300mg per day dipstick Proteinuria; > 300 mg/day
How much of urine do you Secrete and Excrete in a day?
GFR 180 liters/day
E=F-R
GFR, Clearance, Renal Autoreg,
Renal Handling of Glucose
Renal language
Freely filtered : solute filtered with the plasma water Px = BCx Filtered ‘Load’ : rate of filtration of a solute GFR multiply Px (mg/time)
Excreted Load : rate of excretion : Urine flow rate, V multiply Ux
Ux.V /Px
Excreted load/plasma [ ]
- What is excreted is cleared from the plasma into the urine -What is excreted must have originally come from the plasma
-What ‘volume of plasma’ has been cleared of this amount of excreted solute found in urine - ‘Renal clearance’
Unique Inulin
Filtered load = Excreted load GFR x PIN = V x UIN
GFR = =
UIN x V / PIN the excreted load ‘cleared’ of a volume of plasma/time
GFR = Renal Clearance of Inulin
(ml/min)
James Augustine Shannon 1904-1994
Inulin, a biologically inert polysaccharide, can be used to estimate the glomerular filtration rate since it is filtered, but not reabsorbed or secreted.
Renal Clearance…… is it Clear?
Clearance of plasma protein z _ E=z_ Clearance of glucose F = z_ z_ E= z_ _ /_ F = GFR x PG _ /_
E=F–R+S
Clearance = Excr load, UxV/ [Plasma]x = ml [plasma] / min
CCr = Ucr .V/ PCr
Muscle
metabolism
B
Pgc
Ppt
GFR = Kf (net filtration pressure) = Kf (Pgc - Pbc - *gc ) Pgc *gc af ~~~~~~~~~~~~~~~ef
Pbc
Kf - water permeability - total surface area for filtration GFR= 120 ml/min ? liters/day Mesangial cells ECF , (TBW, 42 liters)
PeeSS RBF?
Arthur Vander
When renal sympathetic nerve is stimulated, the glomerular capillary hydrostatic pressure A. will increase B. will decrease C. may or may not decrease D. I don’t like Starling
D. this question stimulates my para-sympathetic and makes me want to pee
Net Filtration Pressure
GFR
gender body size age
ml/min per 1.73m2
microAlbuminuria;
30 - 300mg per day dipstick Proteinuria; > 300 mg/day
How much of urine do you Secrete and Excrete in a day?
GFR 180 liters/day
E=F-R
GFR, Clearance, Renal Autoreg,
Renal Handling of Glucose
Renal language
Freely filtered : solute filtered with the plasma water Px = BCx Filtered ‘Load’ : rate of filtration of a solute GFR multiply Px (mg/time)
Excreted Load : rate of excretion : Urine flow rate, V multiply Ux
Ux.V /Px
Excreted load/plasma [ ]
- What is excreted is cleared from the plasma into the urine -What is excreted must have originally come from the plasma
-What ‘volume of plasma’ has been cleared of this amount of excreted solute found in urine - ‘Renal clearance’
Unique Inulin
Filtered load = Excreted load GFR x PIN = V x UIN
GFR = =
UIN x V / PIN the excreted load ‘cleared’ of a volume of plasma/time
GFR = Renal Clearance of Inulin
(ml/min)
James Augustine Shannon 1904-1994
Inulin, a biologically inert polysaccharide, can be used to estimate the glomerular filtration rate since it is filtered, but not reabsorbed or secreted.
Renal Clearance…… is it Clear?
Clearance of plasma protein z _ E=z_ Clearance of glucose F = z_ z_ E= z_ _ /_ F = GFR x PG _ /_
E=F–R+S
Clearance = Excr load, UxV/ [Plasma]x = ml [plasma] / min
CCr = Ucr .V/ PCr
Muscle
metabolism