The measles pathogenesis started with infection of a host through respiratory droplets, followed by viral replication in the epithelial cells of the respiratory tract and dissemination to lymphatic tissue. However, recent data from animal models suggest that the measles virus first infects mononuclear cells in the lung alveoli, followed by viral replication in bronchus-associated lymphoid tissue and tracheobronchial lymph nodes, which then leads to systemic viremia. Transmission to the next host occurs through aerosols, which include either cell-free virions or infected
The measles pathogenesis started with infection of a host through respiratory droplets, followed by viral replication in the epithelial cells of the respiratory tract and dissemination to lymphatic tissue. However, recent data from animal models suggest that the measles virus first infects mononuclear cells in the lung alveoli, followed by viral replication in bronchus-associated lymphoid tissue and tracheobronchial lymph nodes, which then leads to systemic viremia. Transmission to the next host occurs through aerosols, which include either cell-free virions or infected