Notch Signaling Pathway Summary
Justin Morgan
4/26/17
Homework Summary
Summary of pathway presentations
1. CNTF Signaling Pathway
Ciliary neurotrophic factor receptor (CNTF) also known as Akt contains three isoforms and regulates metabolism etc. Activation occurs down stream of P1-3K pathway. GSK is important and dysregulation of PK3 leads to Cancer, Diabetes and Schizophrenia.
2. Notch Signaling Pathway
The Notch signaling pathway is a fundamental signaling system used by neighboring cells to communicate with each other in order to assume their proper developmental role. Notch proteins are cell surface transmembrane-spanning receptors which mediate critically important cellular functions through direct cell-cell contact. Interaction between Notch and its proposed ligands …show more content…
Hedgehog Gene Pathway
Hedgehog pathway is essential for normal embryonic development and plays critical roles in adult tissue maintenance, renewal and regeneration. Secreted Hedgehog proteins act in a concentration- and time-dependent manner to initiate a series of cellular responses that range from survival and proliferation to cell fate specification and differentiation. Examples were drosophila that came out hairy; Mice came out smaller with a shorter lifespan and over expression of ligand can lead to cancer and birth defects as seen in the …show more content…
D1 receptors signal through G proteins to activate adenylate cyclase, causing cAMP formation and activation of PKA. D2-type receptors block this signaling by inhibiting adenylate cyclase. Parkinson’s disease can occur through both genetic mutation and exposure to environmental and neurotoxins. Recessively inherited mutations in Parkinson’s, DJ-1, and PINK1 cause mitochondrial dysfunction and accumulation of ROS, whereas dominantly inherited missense mutations in LRRK2 may affect protein degradation pathways, leading to protein aggregation and accumulation of Lewy bodies.
9. TNF Signaling Pathway
TNF has been considered as an anti-cancer agent since its discovery. TNF plays important roles in cell proliferation, differentiation, apoptosis, and modulation of immune responses and induction of inflammation. TNF acts through two receptors, TNFR1 and TNFR2. TNFR1 is expressed by all human tissues and is the major signaling receptor for TNF-Alpha and TNFR2 is mostly expressed in immune cells.
10. HIPPO
4/26/17
Homework Summary
Summary of pathway presentations
1. CNTF Signaling Pathway
Ciliary neurotrophic factor receptor (CNTF) also known as Akt contains three isoforms and regulates metabolism etc. Activation occurs down stream of P1-3K pathway. GSK is important and dysregulation of PK3 leads to Cancer, Diabetes and Schizophrenia.
2. Notch Signaling Pathway
The Notch signaling pathway is a fundamental signaling system used by neighboring cells to communicate with each other in order to assume their proper developmental role. Notch proteins are cell surface transmembrane-spanning receptors which mediate critically important cellular functions through direct cell-cell contact. Interaction between Notch and its proposed ligands …show more content…
Hedgehog Gene Pathway
Hedgehog pathway is essential for normal embryonic development and plays critical roles in adult tissue maintenance, renewal and regeneration. Secreted Hedgehog proteins act in a concentration- and time-dependent manner to initiate a series of cellular responses that range from survival and proliferation to cell fate specification and differentiation. Examples were drosophila that came out hairy; Mice came out smaller with a shorter lifespan and over expression of ligand can lead to cancer and birth defects as seen in the …show more content…
D1 receptors signal through G proteins to activate adenylate cyclase, causing cAMP formation and activation of PKA. D2-type receptors block this signaling by inhibiting adenylate cyclase. Parkinson’s disease can occur through both genetic mutation and exposure to environmental and neurotoxins. Recessively inherited mutations in Parkinson’s, DJ-1, and PINK1 cause mitochondrial dysfunction and accumulation of ROS, whereas dominantly inherited missense mutations in LRRK2 may affect protein degradation pathways, leading to protein aggregation and accumulation of Lewy bodies.
9. TNF Signaling Pathway
TNF has been considered as an anti-cancer agent since its discovery. TNF plays important roles in cell proliferation, differentiation, apoptosis, and modulation of immune responses and induction of inflammation. TNF acts through two receptors, TNFR1 and TNFR2. TNFR1 is expressed by all human tissues and is the major signaling receptor for TNF-Alpha and TNFR2 is mostly expressed in immune cells.
10. HIPPO