Preview

Organ Tropism Research Paper

Good Essays
Open Document
Open Document
596 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
Organ Tropism Research Paper
Theory on the Role of Cancer Stem Cells in the Organ Tropism of Breast Cancer Metastasis

Organ Tropism

This paper is on the role of cancer stem cells in the organ tropism of breast cancer metastasis. Cancer mortality is increasing despite vast research efforts. This paper will discuss the characteristics of cancer stem cells and their potential microenvironments. I will focus on a theory of treatment for breast cancer and the role of cancer stem cells in organ tropism.

Adult stem cells can self-renew and are multipotent. Only 0.5% of blood-forming cells are stem cells. (Huether & McCance, 2012, p. 238) Organ tropism is the preferential growth of cancer cells to travel to certain organs. What makes cancer cells …show more content…
The poor prognosis for patients with metastatic breast cancer and toxic side effects of currently available treatments necessitate the development of effective tumor-selective therapies. Neural stem cells (NSCs) possess inherent tumor tropic properties that enable them to overcome many obstacles of drug delivery that limit effective chemotherapy strategies for breast cancer. We report that increased NSC tropism to breast tumor cell lines is strongly correlated with the invasiveness of cancer cells. Interleukin 6 (IL-6) was identified as a major cytokine mediating NSC tropism to invasive breast cancer cells. We show for the first time in a preclinical mouse model of metastatic human breast cancer that NSCs preferentially target tumor metastases in multiple organs, including liver, lung, lymph nodes, and femur, versus the primary intramammary fat pad tumor. For proof-of-concept of stem cell-mediated breast cancer therapy, NSCs were genetically modified to secrete rabbit carboxyl esterase (rCE), an enzyme that activates the CPT-11 prodrug to SN-38, a potent topoisomerase I inhibitor, to effect tumor-localized chemotherapy. In vitro data demonstrate that exposure of breast cancer cells to conditioned media from rCE-secreting NSCs (NSC.rCE) increased their sensitivity to CPT-11 by 200-fold. In vivo, treatment of tumor-bearing mice with NSC.rCE cells in combination with CPT-11 resulted in
Continue Reading
View Writing Issues

You May Also Find These Documents Helpful

  • Good Essays

    Bio Quiz
    • 1403 Words
    • 6 Pages

    Bio Quiz

    What is the name of the process by which cancer cells break off of tumors and spread to other parts of the body?…

    • 1403 Words
    • 6 Pages
    Good Essays
    Read More
  • Good Essays

    Organ Trail Research Paper
    • 240 Words
    • 1 Page

    Organ Trail Research Paper

    The organ trail is a long journey from about 1811-1840 the organ trail was laid down by traders and fur trappers. It could only traveled by horseback or on foot. By the year 1836,the first of the migrant train of wagons was put together. It started in Independence,Missouri and traveled a cleared trail that reached to fort Hall Idaho. In the mid-lath century,the organ trail was the main pathway for Americans emigrants searching for new lands and opportunity on the frontier.…

    • 240 Words
    • 1 Page
    Good Essays
    Read More
  • Satisfactory Essays

    Henry Biology Research Paper
    • 428 Words
    • 1 Page

    Henry Biology Research Paper

    can become all different cell types of the body and Adult stem cells are commonly…

    • 428 Words
    • 1 Page
    Satisfactory Essays
    Read More
  • Powerful Essays

    Nursing 151 Cancer notes
    • 4453 Words
    • 18 Pages

    Nursing 151 Cancer notes

    but also stem cells in many tissues of our body, called mature or adult stem cells…

    • 4453 Words
    • 18 Pages
    Powerful Essays
    Read More
  • Better Essays

    The Effect of Bone Marrow Cancers
    • 1604 Words
    • 7 Pages

    The Effect of Bone Marrow Cancers

    Bone marrow cancers are cancers that involve uncontrolled division of white blood cells or their present in the bone marrow. Hematopoietic process is regulated through mechanisms involving chemical messengers of the immune system. In any way if a failure was to occur with these messengers mechanisms, this can lead to the uncontrolled division of immature blood cells which creates the rise to the cancer. All blood cells arise from multipotent stem cells called hematopoietic stem cell (HSC). This HSC gives rise to two types of cells termed as myeloid progenitor and lymphoid progenitor. Myeloid progenitor and lymphoid progenitor gives the rise to red blood cells and different types of white blood cells. Such a failure can occur due to variety of reasons including, spontaneous gene mutation due to chemicals and radiations, chromosomal aberrations, etc. Bone cancer life expectancy is dependent on many factors from early detection of symptoms, type…

    • 1604 Words
    • 7 Pages
    Better Essays
    Read More
  • Satisfactory Essays

    Reliable Sources Worksheet
    • 632 Words
    • 3 Pages

    Reliable Sources Worksheet

    Date July-Sept 2014 Title Multimodal Treatment of aggressive forms of Breast Cancer Publication July 1, 2014 Write a 100- to 150-word response to each of the following questions Is the source reliable How do you know Yes this source is reliable because of the accuracy of all my information given to be from my sources. The Author is an MD inside of a surgery clinic at Coltea Hospital. She gives her email address and her personal phone number. She has a link to take you to her organization. I believe this source is credible because the topic is covered more…

    • 632 Words
    • 3 Pages
    Satisfactory Essays
    Read More
  • Good Essays

    Stem Cell Informative Speech
    • 272 Words
    • 2 Pages

    Stem Cell Informative Speech

    First, where do stem cells come from, and what properties do they exhibit that make them stem cells? Human embryonic stem cells come from an embryo that develops from an egg. These eggs were originally collected for reproductive purposes. The eggs are fertilized in vitro, and the embryo is donated for research. The donation only happens after the eggs are no longer needed. The donor is informed of the intended use, and consent has been given. These stem cells are found when the embryo is between three and five days old. The embryo, at this point in development, is called a blastocyst. It is the inner group of cells in the blastocyst that contains the stem cells. “Stem cells have three unique properties: they can divide and renew themselves for long periods; they are unspecialized; and they can give rise to specialized cell types ("What Are the Unique Properties of All Stem Cells?").”…

    • 272 Words
    • 2 Pages
    Good Essays
    Read More
  • Good Essays

    Cancer Informative Speech
    • 462 Words
    • 2 Pages

    Cancer Informative Speech

    The place where cancer starts to grow is called the primary site. Although some cancers may spread to more than one area of the body to form multiple secondaries or metastases. In order to spread, some cells from the primary cancer must break away, travel to another part of the body and start growing there. Cancer cells don't stick together…

    • 462 Words
    • 2 Pages
    Good Essays
    Read More
  • Good Essays

    Chris Wark
    • 649 Words
    • 3 Pages

    Chris Wark

    The vital thing about this type of cancer is that they are much more grounded and stronger to common oncology medicines. This implies regardless of the possibility that even if the procedure get rids of the most of the cancer cells, the stem cells is untouched and will be the main cause to create more cancer cells in the future. This is fundamentally the main cause behind why these cancer cells returns after therapy.…

    • 649 Words
    • 3 Pages
    Good Essays
    Read More
  • Best Essays

    Breast Cancer Final
    • 3967 Words
    • 16 Pages

    Breast Cancer Final

    About 1 in 8 U.S. women (just under 12%) will develop invasive breast cancer over the course of her lifetime. In 2011, an estimated 230,480 new cases of invasive breast cancer were expected to be diagnosed in women in the U.S., along with 57,650 new cases of non-invasive breast cancer (U.S. Breast Cancer Statistics, 2012). According to the Centers for Disease Control (CDC), 210,203 women in the United States were diagnosed with breast cancer in 2008, and 40,589 women in the…

    • 3967 Words
    • 16 Pages
    Best Essays
    Read More
  • Best Essays

    Should Embryonic Stem Cell Research Be Banned
    • 3049 Words
    • 13 Pages

    Should Embryonic Stem Cell Research Be Banned

    Stem-cells are actually cells that have not undergone complete development, or, in other words did not differentiate into the cell of a specialized tissue or organ. They possess two important characteristics: they can undergo numerous cycles of cell-division or producing a large number of its own kind, yet at the same time possess the capacity of differentiating into a cell of any tissue or organ of the body.…

    • 3049 Words
    • 13 Pages
    Best Essays
    Read More
  • Powerful Essays

    Transformation Microbiology Lab Term Paper
    • 1980 Words
    • 8 Pages

    Transformation Microbiology Lab Term Paper

    5. Botlagunta M, Winnard PT, Raman V. 2010. Neoplastic Transformation of Breast Epithelial cells by genotoxic stress. BMC Cancer 2010, 10:343 doi:10.1186/1471-2407-10-343.…

    • 1980 Words
    • 8 Pages
    Powerful Essays
    Read More
  • Good Essays

    Benefits Of Embryonic Stem Cell Research
    • 924 Words
    • 4 Pages

    Benefits Of Embryonic Stem Cell Research

    Adult stem cells can develop into the same type of cell from which they were taken. For example, and adult stem cell extracted from bone marrow, could potentially grow into new bone marrow. This is characterized as multipotent. However an embryonic stem cells can possibly develop into any new type of cell, such as cardiac, lung, muscle and nerve cells. This ability is categorized as pluripotent. The potential to treat a large number of diseases with adult stem cells is much lower than with embryonic, because adult stem cells are not able to differentiate into as many types of cells as can embryonic stem cells. An advantage to using adult stem cells is that a patient's own cells are transplanted back into the patient, which intern eliminates the possibility of rejecting the cells and does not require a need for immune suppressing drugs to counter the rejection of the new cells. However adult stem cells have a greater chance of having already developed genetic abnormalities over time, limiting their potential use in medical therapies. With the use of embryonic stem cells, strong immune suppressing drugs may be required to fight of the rejection of the new cells placed into the body. Not only do the two primary stem cells differ in their ability to develop into complete organisms, but they also differ in their…

    • 924 Words
    • 4 Pages
    Good Essays
    Read More
  • Powerful Essays

    Vulnerable Populations in the Workplace
    • 1343 Words
    • 6 Pages

    Vulnerable Populations in the Workplace

    Neighbors, M. & Tannehill-Jones, R. (2006). Human diseases (2nd ed.). [University of Phoenix Custom Edition e-text]. Clifton Park, NY: Thomson Delmar Learning. Retrieved February 6, 2011, from University of Phoenix website.…

    • 1343 Words
    • 6 Pages
    Powerful Essays
    Read More
  • Good Essays

    Stem Cell Research Speech Outline
    • 486 Words
    • 2 Pages

    Stem Cell Research Speech Outline

    - According to University of Nebraska Medical Center, Stem cells are the foundation cells for every organ and tissues in our body.…

    • 486 Words
    • 2 Pages
    Good Essays
    Read More

Related Topics