Preview

PPWD1 Case Study

Good Essays
Open Document
Open Document
902 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
PPWD1 Case Study
IVD Antibody Development Services for PPWD1 Marker

PPWD1:
Cyclophilins consist of one of the three classes of peptidylprolyl isomerases discovered in all prokaryotic and eukaryotic organisms, together with viruses. Most of the seventeen human cyclophilins with the catalytic domain are in tandem with other domains, but many particular functions of a specific cyclophilin or its relevant domains remain unclear.
The structure of the isomerase domain from a spliceosome-correlated cyclophilin, PPWD1 which is known as peptidylprolyl isomerase domain and WD repeat containing 1 or peptidylprolyl isomerase containing WD40 repeat, has been solved to 1.65 A ˚. PPWD1 acts as a protein-coding gene and its related pathways are mRNA splicing. An important paralog of this gene is PPIL2. This polypeptide encodes an N-terminal WD40 repeat domain as well as a C-terminal domain homologous to Cyps. PPWD1 was previously
…show more content…
It is currently the fourth leading cause of cancer mortality in both men and women. Although there are advances in understanding the tumorous biology of pancreatic cancer development, molecularly targeted therapies have not been translated into substantially improved prognosis of this deadly cancer. Here, Creative Biolabs works as a famous expert in in vitro diagnostics (IVD) antibodies and services in order to deal with the prevention and interception of unsolved diseases. The novel targets or agents for clinical therapies are urgently needed and most likely arise from the identification of modifiable risk factors. Indeed, the IVD antibody of PPWD1 maker has been provided in Creative Biolabs for the detection of pancreatic cancers. The IVD productions will assist our clients forming a more detailed comprehension of the molecular mechanisms which stimulate the promotion and progression of pancreatic

You May Also Find These Documents Helpful

  • Satisfactory Essays

    Nt1310 Unit 8 Assignment

    • 459 Words
    • 2 Pages

    In this paper you will find 3 factors that could affect splicing performance, 3 intrinsic factors, and 3 extrinsic factors.…

    • 459 Words
    • 2 Pages
    Satisfactory Essays
  • Good Essays

    Dna Synopsis

    • 1063 Words
    • 5 Pages

    and transferred to _R_ __ __ __ __ __ __ __ __ in the cytoplasm to be translated into a protein…

    • 1063 Words
    • 5 Pages
    Good Essays
  • Satisfactory Essays

    There are multiple ways your cells can read a sequence of DNA and build slightly different proteins from the same strand. We will not go through the process here, but as an illustration of this “alternate splicing”, remove codons (beads) 52 - 66 from your sentence above.…

    • 624 Words
    • 3 Pages
    Satisfactory Essays
  • Good Essays

    Preferred provider organizations (PPOs) are a private plan which is the most popular, followed by health maintenance organizations (HMOs). PPOs sometimes pay participating providers based on a discount from their physician fee schedules which is called a discounted fee-for-service. With a PPO the patient pays annual premiums and often a deductible. The patient has two choices with the first being offered a low deductible with a higher premium and the second being a high deductible with a low premium and they always pay a copayment at the time medical services are rendered. Consumer-driven health plans (CDHPs) combine two components with the first being a high-deductible…

    • 738 Words
    • 3 Pages
    Good Essays
  • Satisfactory Essays

    01 04H WH RobertWellen

    • 474 Words
    • 2 Pages

    El-Khatib, Russell SJ, FH. "Progress in Artificial Pancreas Development: Preventing and Treating Low Blood Glucose." American Diabetes Association. Novo Nordisk Inc., n.d. Web. 08 Sept. 2014.…

    • 474 Words
    • 2 Pages
    Satisfactory Essays
  • Good Essays

    The 1920’s was a very important time in the history of Diabetes and insulin discovery and synthesis. In 1920, Frederick Banting returned from war. He was a struggling physician with a big dream = to solve the mystery that is Diabetes Mellitus. He had this idea: ‘’Ligate pancreatic ducts of dogs. Wait 6-8 weeks for degeneration. Remove the residue and extract.’’ However, he did not have the physical or financial resources to further explore the idea. (Harrison) He then returned to his alma mater, the University of Toronto, and requested the assistance of J.J.R. Macleod who was a world renowned physiologist. J.J.R Macleod…

    • 479 Words
    • 2 Pages
    Good Essays
  • Good Essays

    Around 1790, there were 700,000 slaves in the United States. And by 1860, the number of slaves moved up to 4 million (lecture). The reason why the numbers had changed so drastically was because of the cotton boom. The cotton growing was concentrated on plantations rather than the small farms. Around 75% of slaves lived in groups of around 10 or more slaves, which made changes in the African American slave communities and culture (lecture). With the slave communities developing, they were very unstable. Around 1 million slaves migrated from the upper to lower south, which split the communities and families apart. Since the slave communities were growing, Southern African American communities were different from other slave groups such as Cuba where they constantly imported slaves from Africa. With being a slave, it resulted in a lot of health challenges but the planters tried to keep them healthy enough to work. The death rate for the slave children were rather high because the women worked hard and were not nourished enough. Their masters provided them with food and supplemented the food by growing and hunting (lecture). The slave children did not work the fields at the start of their lives. They were to observe how to survive as slaves. They learned what the penalties were for disobedience and observed how white men violated black women. They saw how slaves were sold away for punishment and also for profit. The older children were to take care of the younger ones and there was no schools for the slave kids. Adult slaves served as servants, artisans, skilled workers, or most were field workers. Most of the skilled workers were men rather than women. Around 75% worked in the field directly affected by the cotton plantation labor system (lecture). With the cotton, it demanded a year rounds worth of labor. The owners divided the slaves up into 20-25 slaves. At harvest they would work 18-hour days. In the evening the women would…

    • 822 Words
    • 4 Pages
    Good Essays
  • Good Essays

    Clopidogrel Case Study

    • 208 Words
    • 1 Page

    Clopidogrel is a thienopyridine prodrug that requires hepatic biotransformation to form an active metabolite that selectively and irreversibly inhibits the purinergic P2RY12 receptor, and thereby platelet aggregation, for the platelet's life span (~10 days). Only 15% of the prodrug is available for transformation to the active agent; the other 85% is hydrolyzed by esterases to inactive forms. Conversion of clopidogrel to its active metabolite requires two sequential oxidative steps involving several CYP450 enzymes (e.g., CYP1A2, CYP2B6, CYP2C9, CYP2C19, and…

    • 208 Words
    • 1 Page
    Good Essays
  • Best Essays

    Ppt Dq Research Paper

    • 2066 Words
    • 9 Pages

    Individual and LT DQs, weekly reflection, and individual paper. For the individual paper (use your Leadership Plan from LDR/711A) and prepare a short PPT addressing these points:…

    • 2066 Words
    • 9 Pages
    Best Essays
  • Good Essays

    Pancreas and Mayo Clinic

    • 1644 Words
    • 6 Pages

    You may be asking yourself, “What is pancreatic cancer?” Pancreatic cancer is a disease caused by malignant (cancer) exocrine cells in the head of the pancreas. (National Cancer Institute). The exocrine cells make up about ninety-five percent of all the cells in the pancreas. (American Cancer Society, 2014). Pancreatic cancer is also called exocrine cancer or pancreatic adenocarcinoma. (Mayo Clinic, 1998-2014). Pancreatic cancer is the fourth leading cause of cancer-related death in the United States. (Frazier, Margaret, 2013). By the time symptoms appear it is too late, the cancer is well advanced and surgical removal is not possible. (Mayo Clinic, 1998-2014).…

    • 1644 Words
    • 6 Pages
    Good Essays
  • Good Essays

    Pancreatic cancer begins in the tissues of the pancreas, the pancreas secretes enzymes that aid digestion and hormones that help regulate sugars. Cancer begins to form when a cell in the pancreas begins to reproduce uncontrollably and crowds out normal cells.…

    • 725 Words
    • 3 Pages
    Good Essays
  • Powerful Essays

    Pancreatic Cancer

    • 1733 Words
    • 7 Pages

    Currently there is no reliable way to diagnosis early detection of pancreatic cancer (Li, G., Huang, Y., Manjunath, Y., Kimchi, E. T., Kaifi, J. T., & Staveley-O'Carroll, K. F. 2016)., However, there are symptoms of pancreatic cancer that can be used as helpful hints in detecting cancer cells such as, yellow skin and eyes, darkening of the urine, itching, and clay-colored stool, which are signs of jaundice caused by a blockage of the bile ducts, pain in upper abdomen or upper back, painful swelling of an arm or leg due to a blood clot, burning feeling in stomach or other gastrointestinal discomforts, stomach bloating, floating stools with a particularly bad odor and an unusual color due to the body not digesting fats well, weakness, loss of appetite, nausea and vomiting, Chills, fever, and unexplained weight loss (Pancreatic Cancer: Diagnosis. 2017). Clinical guidelines suggest that a preoperative assessment should be done on patient with pancreatic cancer to determine the right direction in which the patient should take when diagnosed with cancer.…

    • 1733 Words
    • 7 Pages
    Powerful Essays
  • Good Essays

    The Elusive Prions and CJD: possible to treat? Introduction to Prion Disease Prion disease is an infectious neurodegenerative disease caused by a naturally occurring protein (PrPC) misfolding into an aberrant form (PrPSC) which aggregates and destroys neuronal tissue. PrPSC was originally posited by Stanley Prusiner to be the sole causative moiety in prion disease (Prion Theory), however there is some evidence to suggest that unknown toxic intermediates, co-factors, and certain nucleic acids may have roles to play in its pathogenesis. In humans the diseases are named Creutzfeldt-Jakob Disease (CJD), GerstmannSträussler-Scheinker (GSS) syndrome, Fatal Familial Insomnia (FFI) and kuru. These conditions differ in aetiology, the cause…

    • 759 Words
    • 4 Pages
    Good Essays
  • Good Essays

    Pancreatic cancer, a disease primarily affecting elderly on the range of 60 of age and above, has ranked as fourth causes of cancer-related death with the 5-year survival rate less than 5% in the United State. As reported by (Morana et al., 2010), the prevalence of tumors originated in the pancreatic head is 60%, 15% in the body while 5% of pancreatic tumors originate in the tail. The pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer originating from the pancreatic head. A review reported by (Oberstein and Olive, 2013) has stated that the difficulty of detecting and treating the pancreatic diseases are related with the anatomical nature of the pancreas and the occurrence of the diseases in an advanced age of patients. The pancreas is a retroperitoneal organ, situated at the deep of the abdominal region. It is surrounded by other abdominal organs; the liver superiorly, the abdomen anteriorly, the spleen and small intestine. The head of pancreas, in addition, is inclusively surrounded by the duodenum curve of the small intestine (Applegate, 2010). The inherent location of the…

    • 429 Words
    • 2 Pages
    Good Essays
  • Satisfactory Essays

    CANCER OF THE PANCREAS

    • 302 Words
    • 1 Page

    Pancreatic cancer is more common in men than women and is linked to cigarette smoking, high protein and fat food diets, food additives, and exposure to industrial chemicals like beta naphthalene, benzidine, and urea. Chronic alcohol abuse, chronic pancreatitis, and diabetes mellitus increase the risk of developing pancreatic cancer. One way to control the way one is eating can help reduce the risk of getting pancreatic cancer. If all you eat is high protein and fats in your food you run the risk of getting pancreatic cancer. You can also help reduce your risk for getting this disease by cutting back on the amount you smoke. Although I know it is hard to quit from experience even if you cut back until you realize you do not need to smoke them anymore can be of a great help. This concludes my report on cancer of the pancreas.…

    • 302 Words
    • 1 Page
    Satisfactory Essays

Related Topics