Pharmacokinetics Case Study
Pharmacokinetics and Pharmacodynamics
Scenario
Once a patient is admitted to the hospital, one key element is asked before a medication can be prescribe. That is the patient allergy. As mention in the media presentation, “no one drug works for every patient and you can never say a patient will not have a bad reaction to a drug” (Laureate Education, 2012) I can recalled a particular situation a few years ago with the administration of Narcan (naloxone). One morning during rounds, I received EB with a Demerol (Meperdine) infusing of patient control analgesic (PCA). I began to introduce myself to the patient but no verbal response from the patient. I rub the patient sternum, but still no response. V/S were abnormal. I called the doctor and explain …show more content…
The four stage that occurs after administration, (1) absorption, (2) distribution, (3) metabolism and (4) excretion of drugs. Follow by the concentration of the medication in the plasma and the site of action. The clinician can determine the onset and duration of the medication, by checking for therapeutic results with blood draw to avoid toxicity. In order for the treatment to be effective, medication should be at their therapeutic range. Pharmacodynamics refers to the action of the medication on the individual personal. Looking at the relationship between the drug concentration at the site of action and the resulting outcome. This includes, the time progression, intensity of therapeutic effect and also the adverse effect. Once the medication binds to the receptors site as in the cell membrane or intracellular proteins and the extracellular and cytoplasmic enzymes thus initiating a chain of biochemical event. As in Epinephrine, (Agonism) which produces vasoconstriction in a person with an allergic reaction to a medication. “Knowing the relationship between the drug concentration and response allows the practitioner to take into account the various pathologic and physiologic features of a particular patient that makes his or her response different from the average person’s response to a drug” (Arcangelo & Peterson, 2013, P.
Scenario
Once a patient is admitted to the hospital, one key element is asked before a medication can be prescribe. That is the patient allergy. As mention in the media presentation, “no one drug works for every patient and you can never say a patient will not have a bad reaction to a drug” (Laureate Education, 2012) I can recalled a particular situation a few years ago with the administration of Narcan (naloxone). One morning during rounds, I received EB with a Demerol (Meperdine) infusing of patient control analgesic (PCA). I began to introduce myself to the patient but no verbal response from the patient. I rub the patient sternum, but still no response. V/S were abnormal. I called the doctor and explain …show more content…
The four stage that occurs after administration, (1) absorption, (2) distribution, (3) metabolism and (4) excretion of drugs. Follow by the concentration of the medication in the plasma and the site of action. The clinician can determine the onset and duration of the medication, by checking for therapeutic results with blood draw to avoid toxicity. In order for the treatment to be effective, medication should be at their therapeutic range. Pharmacodynamics refers to the action of the medication on the individual personal. Looking at the relationship between the drug concentration at the site of action and the resulting outcome. This includes, the time progression, intensity of therapeutic effect and also the adverse effect. Once the medication binds to the receptors site as in the cell membrane or intracellular proteins and the extracellular and cytoplasmic enzymes thus initiating a chain of biochemical event. As in Epinephrine, (Agonism) which produces vasoconstriction in a person with an allergic reaction to a medication. “Knowing the relationship between the drug concentration and response allows the practitioner to take into account the various pathologic and physiologic features of a particular patient that makes his or her response different from the average person’s response to a drug” (Arcangelo & Peterson, 2013, P.