Quinine Compare And Contrast

So our students said, “Wait a minute, I thought you need a huge differences in molecular structure to such a vast difference.” No, you don’t. There is case that this can be shown. Quinidine and quinine are two isomers of each other. Quinine is used for malaria, to treat malaria. Anybody know what quinidine is used for? Quinidine is antiarrhythmic, so it’s used for heart issues. Quinine wouldn’t do that. And all it is, is one different isomer of the same compound. So what that does to student is introduce the concept that you need to not only look at the structure on a piece of paper, on a computer, you need to have some more data, high-throughput screening data, or actual animal in vivo data. So then they are thinking they expand their issues.
Later on today, I believe we are going have a fantastic speaker; world-renowned on the looking on biodegradation and what the affective structure has on biodegradation has the design for that. So introduce the structures that affect rate of biodegradation. We are discussing rates of reaction at this point, rates of hydrolysis. And that gets into the discussion of exposure. If it is not there, if it is broke down, then you are exposure to this chemical is reduces.