By
Raffia Siddique, Hafsa Iftikhar, Rabia Ejaz, Tahira Karim
List of contents
Introduction to Nutrigenomics
Emerging faces of nutrition, nutrigenomics and nutrigenetics
Experimental Approaches and Technologies used in Nutrigenomics
Metabolomics-newest tool for Nutrigenomics
Epigenomics has relation in Nutrigenomics
The importance of single nucleotide polymorphisms
Transcriptomics - Nutrigenomics interrelationship
Transcriptomics and micro-array technology
Proteomics
Proteomic technologies
Biomarkers
Effects of different nutrients on human genome
Elements present in food cause potential damage to human genome
Coffee and cigarettes combat rare liver diseases
Nutrigenomics and Ethical control
Looking forward to things which can resolve the ethical , social, legal issues
Conclusion and future perspective
Nutrigenomics – An emerging field of science and technology unrevealing inter-relationships between nutrients and human genome using modern tools such as Transcriptomics, Metabolomics, Epigenomics and Proteomic
Hafsa Iftikhar, Raffia Siddique, Rabia Ejaz, Tahira Karim and Dr.Alvina-The supervisor
National University of Sciences and Technology
Raffiasiddique_93@hotmail.com,
tahira.karim93@yahoo.com, rabiaejaz28@hotmail.com, hafsaiftikhar3@gmail.com
Abstract
Nutrigenomics is emerging field in 20th century, as the old maxim “we are what we eat”. Nutrition and genetics both are play significant role in the maintenance of human health as well as the development of lethal diseases. Genetic variations toward dietary response and the nutrients response in gene expression can also be explored by nutrigenetics and nutrigenomics According to different research studies nutrients is also having the
References: ANDERSEN, I. M., TENGESDAL, G., LIE, B. A., BOBERG, K. M., KARLSEN, T. H. & HOV, J. R. 2013. Effects of Coffee Consumption, Smoking, and Hormones on Risk for Primary Sclerosing Cholangitis. Clin Gastroenterol Hepatol. BAXTER, A. J., COYNE, T. & MCCLINTOCK, C. 2006. Dietary patterns and metabolic syndrome--a review of epidemiologic evidence. Asia Pac J Clin Nutr, 15, 134-42. BLUHER, M., WILSON-FRITCH, L., LESZYK, J., LAUSTSEN, P. G., CORVERA, S. & KAHN, C. R. 2004. Role of insulin action and cell size on protein expression patterns in adipocytes. Journal of Biological Chemistry, 279, 31902-31909. BOUCHARD, C. & ORDOVAS, J. M. 2012. Fundamentals of Nutrigenetics and Nutrigenomics. Recent Advances in Nutrigenetics and Nutrigenomics, 108, 1-15. CASTLE, D. & RIES, N. M. 2007. Ethical, legal and social issues in nutrigenomics: the challenges of regulating service delivery and building health professional capacity. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 622, 138-143. CHAKRAVARTI, A. 2001. To a future of genetic medicine. Nature, 409, 822-3. CORBIN, K. D. & ZEISEL, S. H. 2012. The Nutrigenetics and Nutrigenomics of the Dietary Requirement for Choline. Recent Advances in Nutrigenetics and Nutrigenomics, 108, 159-177. CORDERO, P., CAMPION, J., MILAGRO, F. I., MARZO, F. & MARTINEZ, J. A. 2008a. Fat-to-glucose interconversion by hydrodynamic transfer of two glyoxylate cycle enzyme genes. Lipids in Health and Disease, 7. CORDERO, P., CAMPION, J., MILAGRO, F. I., MARZO, F. & MARTINEZ, J. A. 2008b. Fat-to-glucose interconversion by hydrodynamic transfer of two glyoxylate cycle enzyme genes. Lipids Health Dis, 7, 49. CORNELIS, M. C., EL-SOHEMY, A., KABAGAMBE, E. K. & CAMPOS, H. 2006. Coffee, CYP1A2 genotype, and risk of myocardial infarction. Jama-Journal of the American Medical Association, 295, 1135-1141. DAVIS, C. D. & MILNER, J. 2004. Frontiers in nutrigenomics, proteomics, metabolomics and cancer prevention. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 551, 51-64. DE GRAAF, A. A., FREIDIG, A. P., DE ROOS, B., JAMSHIDI, N., HEINEMANN, M., RULLMANN, J. A. C., HALL, K. D., ADIELS, M. & VAN OMMEN, B. 2009. Nutritional Systems Biology Modeling: From Molecular Mechanisms to Physiology. Plos Computational Biology, 5. FRAZER, K. A., MURRAY, S. S., SCHORK, N. J. & TOPOL, E. J. 2009. Human genetic variation and its contribution to complex traits. Nature Reviews Genetics, 10, 241-251. GARCIA-BAILO, B., TOGURI, C., ENY, K. M. & EL-SOHEMY, A. 2009. Genetic variation in taste and its influence on food selection. OMICS, 13, 69-80. HINE, R. J., SRIVASTAVA, S., MILNER, J. A. & ROSS, S. A. 2003. Nutritional links to plausible mechanisms underlying pancreatic cancer: a conference report. Pancreas, 27, 356-66. JONES, K. T. & ASHRAFI, K. 2009. Caenorhabditis elegans as an emerging model for studying the basic biology of obesity. Disease Models & Mechanisms, 2, 224-229. KNOWLES, L. M. & MILNER, J. A. 2003. Diallyl disulfide induces ERK phosphorylation and alters gene expression profiles in human colon tumor cells. Journal of Nutrition, 133, 2901-2906. KUSSMANN, M. & AFFOLTER, M. 2009. Proteomics at the center of nutrigenomics: Comprehensive molecular understanding of dietary health effects. Nutrition, 25, 1085-1093. LENHARD, K., BOMMER, G. T., ASUTAY, S., SCHAUER, R., BRABLETZ, T., GOKE, B., LAMERZ, R. & KOLLIGS, F. T. 2005. Analysis of promoter methylation in stool: a novel method for the detection of colorectal cancer. Clin Gastroenterol Hepatol, 3, 142-9. MCNALLY, R. D. 2006. Acquiring new technology and surviving environmental pressures. Radiol Technol, 77, 191-9. MEMELINK, J. 2004. Putting the opium in poppy to sleep. Nat Biotechnol, 22, 1526-7. ORDOVAS, J. M. 2007. Genetic links between diabetes mellitus and coronary atherosclerosis. Curr Atheroscler Rep, 9, 204-10. ORDOVAS, J. M. & CORELLA, D. 2004a. Nutritional genomics. Annu Rev Genomics Hum Genet, 5, 71-118. ORDOVAS, J. M. & CORELLA, D. 2004b. Nutritional genomics. Annual Review of Genomics and Human Genetics, 5, 71-118. RENGARAJ, V., KANNUSAMY, V. & KRISHNAN, T. 2003. Cortical removal simplified by J-cannula irrigation. J Cataract Refract Surg, 29, 1852-3. RHIND, S. M. 2004. Effects of maternal nutrition on fetal and neonatal reproductive development and function. Anim Reprod Sci, 82-83, 169-81. TARPLEY, L. & VIETOR, D. M. 2007. Compartmentation of sucrose during radial transfer in mature sorghum culm. BMC Plant Biol, 7, 33. TRICHOPOULOU, A., YIANNAKOURIS, N., BAMIA, C., BENETOU, V., TRICHOPOULOS, D. & ORDOVAS, J. M. 2008. Genetic predisposition, nongenetic risk factors, and coronary infarct. Arch Intern Med, 168, 891-6. VAN OMMEN, B. & STIERUM, R. 2002. Nutrigenomics: exploiting systems biology in the nutrition and health arena. Curr Opin Biotechnol, 13, 517-21. WATKINS, S. M., HAMMOCK, B. D., NEWMAN, J. W. & GERMAN, J. B. 2001a. Individual metabolism should guide agriculture toward foods for improved health and nutrition. American Journal of Clinical Nutrition, 74, 283-286. WOODS, C. R. 2003. Lack of association of race/ethnicity and otitis media in the first 2 years of life. Clin Pediatr (Phila), 42, 687-96. WU, G., BAZER, F. W., CUDD, T. A., MEININGER, C. J. & SPENCER, T. E. 2004a. Maternal nutrition and fetal development. J Nutr, 134, 2169-72. WU, G., FANG, Y. Z., YANG, S., LUPTON, J. R. & TURNER, N. D. 2004b. Glutathione metabolism and its implications for health. J Nutr, 134, 489-92. WU, G. Y. & MEININGER, C. J. 2002. Regulation of nitric oxide synthesis by dietary factors. Annual Review of Nutrition, 22, 61-86.