Bio/1101 Unit 1 Study Guide
Name: Nympha Afriyie
Course: Bio 1101 lab
Due date: February 12 2015
Journal 2
Year: March 5th 2004
Journal Name: 2 (two)
Article title: Genome-Wide Scan Identifies Novel QTL’s For Cholesterol and LDL Levels in F2 [Dahl RxS] Intercross Rats
Authors: Victoria L.M, Tamara Didishvili, Lyle V. Lopez, Richard H. Myers, Nelson Ruiz-Opazo
1. What is the disease name of the model/study organism?
Answer: the disease name of the model/study organism is, Coronary artery disease
2. What is one piece of interesting information found in the introduction?
Answer: one piece of interesting information I found in the introduction was that, low-density lipoprotein cholesterol (LDL) has been shown to be the most predictive of atherogenic susceptibility6 and has been demonstrated to exhibit oxidative susceptibility, which then relates to pathogenic oxidative processes implicated in coronary atherosclerotic plaque progression and destabilization.(page 446) …show more content…
3.
What is the major question and/or hypothesis in the journal article?
Answer: the major question and or hypothesis studied in this article is that the more cholesterol present the more coronary heart disease and stroke would be available among people.
4.
a) Where did they sample?
Answer: they did sample in Western countries. (Page 446 2nd sentence)
b) How did they sample?
Answer: For the samples they performed a 121-marker, total genome-analysis of an F2[Dahl RS]-intercross selected for contrasting parental strain susceptibilities for hyperlipidemia on regular rat diets at 6 months of age.(446)
c) Number of samples taken?
Answer: the number of samples taken was four (4)
5.
I. Describe the
experiment.
Answer: on table 4, for the percentage total of variance, the numbers/outcome at the end varied with a little bit of difference as it started at 12 and dropped to 7 throughout.
II. What are the predictor and response variables for this experiments?
Answer: I think the predictor variable is the human homologue and the response variable is the predicted QTL-Peak
III. What evidence did the experiment produce?
Answer: the evidence the experiment produced was how the outcome that cholesterol was found in about half the percentage of people.
IV. Describe how the evidence supported/answered the major hypothesis/question?
Answer: it answered because the outcome/ results showed exactly what we were looking for, because their main point or result they were looking for, was to find the number of people affected, the cure and the cause of it.
6. What was the major conclusion of the study?
Answer: the major conclusion was that the findings on the point to the link between hypercholesterolemia and Left Ventricular Fibrosis in salt-sensitive hypertension of rats which is genetically modulated by RNO19
.
7. CITATION:
L.M, V., Didishvili, T., V. Lopez, L., Myers, R., & Ruiz-Opazo, N. (2004). Genome-Wide Scan Identifies Novel QTL’s For Cholesterol and LDL Levels in F2 [Dahl RxS] Intercross Rats. <i>Circulation Reaserch,</i> <i>16</i>(2), 446,447,448,449,450,451,452,453,454,455-446,447,448,449,450,451,452,453,454,455.
Course: Bio 1101 lab
Due date: February 12 2015
Journal 2
Year: March 5th 2004
Journal Name: 2 (two)
Article title: Genome-Wide Scan Identifies Novel QTL’s For Cholesterol and LDL Levels in F2 [Dahl RxS] Intercross Rats
Authors: Victoria L.M, Tamara Didishvili, Lyle V. Lopez, Richard H. Myers, Nelson Ruiz-Opazo
1. What is the disease name of the model/study organism?
Answer: the disease name of the model/study organism is, Coronary artery disease
2. What is one piece of interesting information found in the introduction?
Answer: one piece of interesting information I found in the introduction was that, low-density lipoprotein cholesterol (LDL) has been shown to be the most predictive of atherogenic susceptibility6 and has been demonstrated to exhibit oxidative susceptibility, which then relates to pathogenic oxidative processes implicated in coronary atherosclerotic plaque progression and destabilization.(page 446) …show more content…
3.
What is the major question and/or hypothesis in the journal article?
Answer: the major question and or hypothesis studied in this article is that the more cholesterol present the more coronary heart disease and stroke would be available among people.
4.
a) Where did they sample?
Answer: they did sample in Western countries. (Page 446 2nd sentence)
b) How did they sample?
Answer: For the samples they performed a 121-marker, total genome-analysis of an F2[Dahl RS]-intercross selected for contrasting parental strain susceptibilities for hyperlipidemia on regular rat diets at 6 months of age.(446)
c) Number of samples taken?
Answer: the number of samples taken was four (4)
5.
I. Describe the
experiment.
Answer: on table 4, for the percentage total of variance, the numbers/outcome at the end varied with a little bit of difference as it started at 12 and dropped to 7 throughout.
II. What are the predictor and response variables for this experiments?
Answer: I think the predictor variable is the human homologue and the response variable is the predicted QTL-Peak
III. What evidence did the experiment produce?
Answer: the evidence the experiment produced was how the outcome that cholesterol was found in about half the percentage of people.
IV. Describe how the evidence supported/answered the major hypothesis/question?
Answer: it answered because the outcome/ results showed exactly what we were looking for, because their main point or result they were looking for, was to find the number of people affected, the cure and the cause of it.
6. What was the major conclusion of the study?
Answer: the major conclusion was that the findings on the point to the link between hypercholesterolemia and Left Ventricular Fibrosis in salt-sensitive hypertension of rats which is genetically modulated by RNO19
.
7. CITATION:
L.M, V., Didishvili, T., V. Lopez, L., Myers, R., & Ruiz-Opazo, N. (2004). Genome-Wide Scan Identifies Novel QTL’s For Cholesterol and LDL Levels in F2 [Dahl RxS] Intercross Rats. <i>Circulation Reaserch,</i> <i>16</i>(2), 446,447,448,449,450,451,452,453,454,455-446,447,448,449,450,451,452,453,454,455.