Sedative Drugs: Subsidiazepines
Sedative drugs include benzodiazepines, barbiturates, and other sleeping pills.
The most commonly prescribed sedatives are benzodiazepines , which are similar to alcohol in that they facilitate the inhibitory effects of gamma-aminobutyric acid at the GABA-A receptor complex, primarily by binding non-selectively to the benzodiazepine subtype 1 and BZ2 receptors.
Some benzodiazepines are directly conjugated via glucuronyl transferase and then excreted, while others are first metabolized by the cytochrome P-450 isozyme 3A4 and/or 3A5.
In addition to reducing anxiety and inducing sleep, benzodiazepines can cause euphoria and are subject to abuse as recreational drugs.
Flunitrazepam is a short-acting benzodiazepine that is available by prescription
The most commonly prescribed sedatives are benzodiazepines , which are similar to alcohol in that they facilitate the inhibitory effects of gamma-aminobutyric acid at the GABA-A receptor complex, primarily by binding non-selectively to the benzodiazepine subtype 1 and BZ2 receptors.
Some benzodiazepines are directly conjugated via glucuronyl transferase and then excreted, while others are first metabolized by the cytochrome P-450 isozyme 3A4 and/or 3A5.
In addition to reducing anxiety and inducing sleep, benzodiazepines can cause euphoria and are subject to abuse as recreational drugs.
Flunitrazepam is a short-acting benzodiazepine that is available by prescription