Change in the body weight is a common effect of antidepressants substances use. Some studies based on antidepressant drugs have been done and they demonstrate that these medications can act as potential factors to increase or decrease weight. The tricycle antidepressant types such as amitriptyline are more likely to intensify and promote weight gain. On the other hand, substances like fluoxetine, paroxetine and sibutramine might lead to weight loss. There are many contrasts when it comes to the mechanism responsible for these variations in body mass. However, it is known that the weight rise can be the cause of different unwelcome future consequences such as type 2 diabetes mellitus, hypertension and other chronicle diseases. When it comes to weight decrease, the antidepressant drug problems are related to nervous system stimulation and it is at this point that the use of diet pills comes from. Most diet pills contain antidepressant constituents that have the power to act in the metabolism as thermogenic and in the activity of neurotransmitters increasing weight loss very quickly. This literature review will discuss the association between weight changes, antidepressant and diet pill intake and their consequences to users. In particular, it will relate the evidences and show the literature contrasts about the usage of antidepressants either as a medication or as a diet pill component.
Keywords: Tricycle antidepressants, Weight gain, Weight loss, Diet aids, Sibutramine
Antidepressants are some of the most prescribed/used medication all over the world (Batty, Geddes et al. 2010). These drugs can be used in many different situations such as depressive episodes, bipolar syndrome, eating disorders and others psychological and/or psychiatric conditions. Many side effects are associated with the use of antidepressants but changes on body weight are very common (Russ and Ackerman 1988). It has been