Written Task: Open Ended Investigation
Aim:
Compare the solubility of various forms of panadol at body temperature in different pH conditions
Hypothesis
Panadol 6 will dissolve faster than any other panadol and all type of panadol will have increase solubility in acidic conditions
Apparatus and Materials * 54 alcohol swabs * Glass thermometer * 600mL pyrex measuring jug (heat resistant, transparent, glass, volumetric measuring instrument) * 54 heat resistant, transparent, plastic cups * 18 Panadol 1 tablets “Panadol - Tablets” (Tablet with Potassium Sorbate Preservative) * 18 Panadol 2 tablets “Panadol – Caplets” (Capsule shaped Tablets with Hydroxybenzoate Preservatives) * 18 Panadol 3 capsules “Panadol – Gel Caps” (Capsule with Potassium Sorbate Preservative and Gelatine Coating) * 18 Panadol 4 capsules “Panadol – Mini Caps” (Capsule with Gelatine Coating) * 18 Panadol 5 tablets “Panado Rapid – Caplets” (Capsule shaped Tablet with Sodium Bicarbonate for accelerated digestion and Potassium Sorbate Preservative) * 18 Panadol 6 tablets “Panadol Rapid – Soluble” (Effervescent Tablets with Sodium Bicarbonate for accelerated digestion) * 1.8L distilled water (neutral solvent) * 1.8L bottled lemon juice (acidic solvent) * 1.35L cloudy ammonia (basic solvent) * 0.45L distilled water (basic solvent dilution) * 2 small saucepans * Stove * Permanent marker
Method
Neutral Solvent 1. Wipe thermometer with ethyl alcohol swab to sterilise 2. Boil 600mL distilled water in a saucepan on stove 3. Use sterilised thermometer to determine the temperature of water and allow to cool to 37⁰C 4. Label a plastic cup “Neutral Solvent, Panadol 1, Trial 1” 5. Measure 100mL of distilled 37⁰C water using measuring jug and pour into labelled cup 6. Add one Panadol 1 to plastic cup, record immediate changes to tablet and solvent 7. Record