Sglt2 Research Paper

SGLT2 is a protein in the kidney that facilitates glucose reabsorption. SGLT2 is located in the proximal tubule of the kidneys. It has low-affinity but is a high capacity glucose transporter. It accounts for 90% of glucose reabsorption in kidneys. Inhibition of SGLT2 causes reduced blood glucose due to increased renal glucose excretion. The mechanism of action of this new class of drugs also offers further glucose control by promoting increased activity of insulin, glucose uptake in the muscle cells, decreased gluconeogenesis and improved first phase insulin release from the beta