Sodium Butyldithiocarbamate Pentahydrate Lab Report
Synthesis, characterization, crystallographic Study and antibacterial activity of sodium butyldithiocarbamate pentahydrate, C5H20NNaO5S2
Ayodele T. Odularu a, Peter A. Ajibade a, Bolhuis, A. b
a. Department of Chemistry, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.
b. Department of Pharmacy and Pharmacology, University of Bath, United Kingdom.
Abstract
Synthesis of sodium butyldithiocarbamate pentahydrate, C5H20NNaO5S2, entailed a one-pot synthesis. The process of synthesis involved the use of butyl amine, carbon(IV) sulfide and sodium hydroxide at a temperature < 0oC. Crystals were obtained and the compound was characterized with elemental analysis, Fourier infra-red spectroscopy (FT-IR), Ultra-violet visible (UV-VIS) …show more content…
aureus, E.faecalis and E. coli using the disk diffusion method, and compared to that of the clinically used antibiotics tetracycline and vancomycin, used as standards. Results can be seen as shown in Table 6. C5H20NNaO5S2 was particularly active to the multidrug-resistant strain S. aureus MRSA252, whereas the compound was moderately active against E. coli and E. faecalis.
Butyl amine, from which C5H20NNaO5S2 was synthesized, showed only moderate activity against MRSA252.
Table 6: Antibacterial activities (zones of inhibition [in mm] on agar plates) of sodium butyldithiocarbamate pentahydrate S. aureus (mm) E. faecalis (mm) E. coli (mm)
BA 10.0 0.0 0.0
C5H20NNaO5S2 40.7 18.0 10.0
DMSO 0.0 0.0 0.0
Tetracycline 30 28
Vancomycin 22
BA: Butyl amine; C5H20NNaO5S2: Sodium butyl dithiocarbamate trihydrate; C=contamination
Standards/Controls: DMSO, Tetracycline and Vancomycin and
Ayodele T. Odularu a, Peter A. Ajibade a, Bolhuis, A. b
a. Department of Chemistry, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa.
b. Department of Pharmacy and Pharmacology, University of Bath, United Kingdom.
Abstract
Synthesis of sodium butyldithiocarbamate pentahydrate, C5H20NNaO5S2, entailed a one-pot synthesis. The process of synthesis involved the use of butyl amine, carbon(IV) sulfide and sodium hydroxide at a temperature < 0oC. Crystals were obtained and the compound was characterized with elemental analysis, Fourier infra-red spectroscopy (FT-IR), Ultra-violet visible (UV-VIS) …show more content…
aureus, E.faecalis and E. coli using the disk diffusion method, and compared to that of the clinically used antibiotics tetracycline and vancomycin, used as standards. Results can be seen as shown in Table 6. C5H20NNaO5S2 was particularly active to the multidrug-resistant strain S. aureus MRSA252, whereas the compound was moderately active against E. coli and E. faecalis.
Butyl amine, from which C5H20NNaO5S2 was synthesized, showed only moderate activity against MRSA252.
Table 6: Antibacterial activities (zones of inhibition [in mm] on agar plates) of sodium butyldithiocarbamate pentahydrate S. aureus (mm) E. faecalis (mm) E. coli (mm)
BA 10.0 0.0 0.0
C5H20NNaO5S2 40.7 18.0 10.0
DMSO 0.0 0.0 0.0
Tetracycline 30 28
Vancomycin 22
BA: Butyl amine; C5H20NNaO5S2: Sodium butyl dithiocarbamate trihydrate; C=contamination
Standards/Controls: DMSO, Tetracycline and Vancomycin and