Michael ABSTRACT in the
with intake
aspartame and body
or weight
G TordoffandAnnette To examine
MAlleva suggest that sweet oral stimulation initiates a cephalic-phase metabolic reflex that increases appetite (10). The long-term effects of artificial sweeteners on food intake and body weight are less clear. Although some investigators report weight gain in animals given artificial sweeteners to eat or drink (1 1-13), the majority reports no effects (11, 14-17). What little work has been done in humans does little to answer the question. Two correlative comparisons ofusers and nonusers of artificial sweeteners showed that the sweeteners had no effect on body weight (18, 19). In contrast, an epidemiological study of 78 694 women found that reported weight gain was greater in those who used artificial sweeteners than in those who did not (20). There are only three published studies that have used a causative amount when approach. ofweight ate APM replaced In one, dieters who two, during were either
whether artificial sweeteners aid intake and body weight, we gave free-living, normal-weight subjects 1 150 g soda sweetened with aspartame (APM) or high-fructose corn syrup (HFCS) per day. Relative to when no soda was given, drinking APM-sweetcontrol of long-term food ened soda for 3 wk significantly reduced calorie intake drinking the of both
females weight sweetened take
(n = 9) and males (n = of males but not of females. soda body for 3 wk significantly and
2 1) and
However,
decreased
the body
HFCScalorie in-
increased
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weight of both sexes. Ingesting either type of soda reduced intake of sugar from the diet without affecting intake of other nutrients. Drinking large volumes of APMsweetened soda, in contrast to drinking HFCS-sweetened soda, reduces sugar intake and thus may facilitate the control of