Successful keloid treatment has still been an obstacle because the current treatments are far away from guarantying cure of the disease and preventing recurrence. This probably due to the lack of an extensive research to study and evaluate those treatments (Gauglitz et al., 2011). There are a wide range of therapies that have been used in treating keloid and hypertrophic scars. Although most of the therapeutic options that we will cover work for both scars, we have to be very careful to differentiate hypertrophic scar from keloid especially before starting the surgical treatment (Gauglitz et al., 2011). Keloid treatment can be divided in to three main categories: Noninvasive medical therapies, surgical and other invasive …show more content…
Corticosteroids treat the keloid by decreases fibroblast proliferation, collagen synthesis, glycosaminoglycan synthesis, and repression the inflammation and mitosis (Wolfram et al., 2009, Rabello FB et al., 2014). Triamcinolone acetonide suspension is used clinically as intralesional injection in concentration ranging between 10 to 40 mg per ml based on the site of injection (Robles et al., 2007). However, it is painful, it flatten the keloid from 50 to 100 percent (Khan, Bashir, & Khan, 2014); therefore, it is usually combined with Lidocaine to lessen pain (Juckett and Adams, 2009). Usually, corticosteroid is given in two or three injections per month, but the therapy might continue for six months or even longer depending on the severity of the case (Robles et al., 2007). Combine of corticosteroid injections with cryotherapy therapy or the surgical management gives a clinical outcomes better than use either one separately (Juckett and Adams, 2009). However, the atrophy, telangiectasias, hypopigmentation are the main and significant side effects of these combinations (Khan et al.,