Synthesis Acetamide Synthesis Report

N-(4-ethoxyphenyl)acetamide. This product was synthesized from acetaminophen in a two step Williamson Either Synthesis. Acetaminophen (250 mg), K2CO3 (0.3 g), and ethyl iodide (0.3 mL) were combined with butanone (5 mL) solvent in a round bottom flask (50 mL capacity). The contents were heated to reflux for one hour. The flask was allowed to cool to room temperature before extraction. The contents were rinsed from the flask in water (10 mL) and ethyl acetate (10 mL) and transferred to a separatory funnel for an extraction to be carried out. A second extraction was conducted with aqueous NaOH (10 mL, 5%) and H2O (10 mL) on the organic layer collected. The combined layers from the base wash were then dried over MgSO4 before being gravity filtered