In the human body, ethanol affects the gamma-aminobutyric acid (GABA) receptors and produces a depressant (neurochemical inhibitory) effect. Ethanol is similar to other sedative-hypnotics such as barbiturates and benzodiazepines both in its effect on the GABAA receptor, although its pharmacological profile is not identical. It has anxiolytic, anticonvulsant, hypnotic, and sedative actions similar to many other sedative-hypnotic drugs. Ethanol is also cross-tolerant with benzodiazepines and barbiturates.[3] In fact, a synthetic alcohol based on benzodiazepines is currently developed by a team at Imperial College London, led by Professor David Nutt (chair of ISCD). The alcohol substitute give the drinker the effects of drunkenness without many of the risks of alcohol;[4] Accordingly to ISCD alcohol was the most harmful of all drugs considered, scoring 72%. Alcohol is the most available and widely abused substance and its chronic consumption causes neurobehavioral disorders.[5] A high-functioning alcoholic (HFA) is a
In the human body, ethanol affects the gamma-aminobutyric acid (GABA) receptors and produces a depressant (neurochemical inhibitory) effect. Ethanol is similar to other sedative-hypnotics such as barbiturates and benzodiazepines both in its effect on the GABAA receptor, although its pharmacological profile is not identical. It has anxiolytic, anticonvulsant, hypnotic, and sedative actions similar to many other sedative-hypnotic drugs. Ethanol is also cross-tolerant with benzodiazepines and barbiturates.[3] In fact, a synthetic alcohol based on benzodiazepines is currently developed by a team at Imperial College London, led by Professor David Nutt (chair of ISCD). The alcohol substitute give the drinker the effects of drunkenness without many of the risks of alcohol;[4] Accordingly to ISCD alcohol was the most harmful of all drugs considered, scoring 72%. Alcohol is the most available and widely abused substance and its chronic consumption causes neurobehavioral disorders.[5] A high-functioning alcoholic (HFA) is a