In addition to these well-established pathophysiological events, evidence acquired in the past recent years indicates that AKI is characterized by significant epigenetic abnormalities, including aberrant DNA methylation, histone modifications, and microRNA (miRNA) expression (13-16); however, there is a lack of knowledge to clarify (i) significance of these changes in AKI and (ii) mechanistic relationship and interplay between different individual epigenetic components in the pathogenesis of
In addition to these well-established pathophysiological events, evidence acquired in the past recent years indicates that AKI is characterized by significant epigenetic abnormalities, including aberrant DNA methylation, histone modifications, and microRNA (miRNA) expression (13-16); however, there is a lack of knowledge to clarify (i) significance of these changes in AKI and (ii) mechanistic relationship and interplay between different individual epigenetic components in the pathogenesis of