vulnificus via proinflammatories interleukin 6 (IL-6), IL-8, and tumor necrosis factor alpha, dominantly expressed during infection. In V. vulnificus when toll-like receptor 2 (TLR2) binds to the surface of a lipoprotein its is associated with the production of TNF-alpha and IL-6 (proinflammatories correlated with infection). Based on research conducted by McPherson, Watts, Simpson, and Oliver (cited in both review articles); direct, intravenous injection of V. Vulnificus LPS in mice resulted in a decrease in “mean arterial pressure and rapid death of the animal, implicating its role in symptom development and lethality” (1). Interestingly, when mice are introduced to LPS along with a nitric oxide synthase inhibitor (such as LDL cholesterol or estrogen), it is reported to diminish the endotoxic activity of LPS. This suggests nitric oxide production (dependent on TNF-alpha stimulation) is responsible for endotoxic shock seen in response to Vibrio vulnificus
vulnificus via proinflammatories interleukin 6 (IL-6), IL-8, and tumor necrosis factor alpha, dominantly expressed during infection. In V. vulnificus when toll-like receptor 2 (TLR2) binds to the surface of a lipoprotein its is associated with the production of TNF-alpha and IL-6 (proinflammatories correlated with infection). Based on research conducted by McPherson, Watts, Simpson, and Oliver (cited in both review articles); direct, intravenous injection of V. Vulnificus LPS in mice resulted in a decrease in “mean arterial pressure and rapid death of the animal, implicating its role in symptom development and lethality” (1). Interestingly, when mice are introduced to LPS along with a nitric oxide synthase inhibitor (such as LDL cholesterol or estrogen), it is reported to diminish the endotoxic activity of LPS. This suggests nitric oxide production (dependent on TNF-alpha stimulation) is responsible for endotoxic shock seen in response to Vibrio vulnificus