The major themes identified by commentators in Of Mice and Men are friendship and isolation, hope and futility(Votteler 334). Through George and Lennie's friendship, the hope to achieve their dream is kept alive. "George, little and clever, feels that Lennie has been given into his keeping"(Moore 341). "Simpleminded and gentle, Lennie possesses great physical strength and becomes unwittingly destructive when startled"(Votteler 334). Although Lennie is very strong, he is also very timid and has trouble remembering things, but under George's control, Lennie is calm and docile since he just does what George tells him to(Moore 341).
According to Moore, "Of Mice and Men tells the story of two drifting ranch hands, George and Lennie, who dream, as rootless men do, of a piece of land of their own, where they will 'belong'"(341). George tells Lennie that the loneliest guys in the world are like them working on ranches, have no family, no place to belong for continually moving on to a new ranch, and have nothing to look forward to(Steinbeck 13). With them, it is not like that because they have a future, somebody to talk to, and are working toward getting their own farm with a couple acres of land(Steinbeck 14). Lennie enjoys the idea of having a farm and tending to the rabbits so much that he begs George to tell the story over and over again(Rascoe 337). George holds Lennie in check by telling him about the farm and the condition that if he is good he will be allowed to tend the rabbits on