color change with ferric chloride. Introduction Acetylsalicylic acid (aspirin) is one of the most popular analgesic drugs on the market today. It also acts as an antipyretic and anti-inflammatory drug. Salicylic acid itself was too acidic and irritating to the membranes of the mouth to be taken in its original form‚ so acetylsalicylic acid was synthesized by a Bayer chemist and sold under the name aspirin. Procedure See lab notebook. Results and Discussion Mass of Salicylic Acid 0.2113 g Volume
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Aspirin Background Aspirin Aspirin‚ or acetylsalicylic acid (ASA) is a salicylate drug‚ and is generally used as an analgesic (something that relieves pain without producing anaesthesia or loss of consciousness) for minor aches and pains‚ to reduce fever (an antipyretic)‚ and also as an anti-inflammatory drug. Aspirin works by prohibiting biological substances such as prostaglandins. Many different prostaglandins exist in the human body each serving a plethora of physical functions.
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Bristol-Myers have been very successful in analgesic market for many years with Aspirin type pain relievers marketed as Bufferin and Excedrin. Together with Bayer Aspirin by Sterling Drug Company‚ three aforementioned aspirin type pain relievers comprised of 90% of Analgesic market. One other type of pain relievers‚ Acetaminophen‚ have emerged into the market and its growth in the market seemed quite significant compared to that of aspirin type pain relievers. Although acetaminophen comprised of less than 10%
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Analytical Chemistry Experiment 2b: Determination of the ASA Content of Aspirin Due Date: September 16‚ 2013 Experiment#: 2b Title: Determination of the ASA Content of Aspirin Aim: To determine the Molar Concentration of NaOH and HCl acid used in their Standardization processes and to determine the acetylsalicylic acid (ASA) content in Aspirin. Materials/Apparatus: materials used are the same as that outlined in the laboratory procedure prepared by the laboratory instructor. Procedure:
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schemes using Dipotassium phosphate (K2HPO4) and Potassium hydroxide (KOH) to isolate the compounds of pure Acetylsalicylic Acid/Aspirin and N-(4-hydroxyphenyl) Ethanimidate/Acetaminophen respectively from Excedrin. The first reaction scheme to undergo acid-base organic extraction was to isolate the most acidic compound in Excedrin with a weak base‚ K2HPO4. We isolated the aspirin using aqueous base extraction‚ with Dipotassium phosphate then treated with HCl to force acidification. The mechanism for Scheme
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the lab was to separate and analyse analgesic drugs in a drug tablet. The method used to separate the components was Thin Layer Chromatography (TLC) with silica adsorbent as the stationary phase and 0.5% glacial acetic as the mobile phase. In one plate‚ five known samples were used as the reference‚ that is: Aspirin; Caffeine; Ibuprofen; and Salicylamide. Aspirin and Salicylamide were the only samples that fluoresced. On a second plate‚ the tablet sample was developed. The results of the lab showed
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Sasha Thiel 09.10.2012 CH203 Lab Experiment 1: Isolation of the Active Ingredient in an Analgesic Drug Pre-Lab: A. Least accurate to most accurate 1. Beakers (5ml markings) 2. 10ml graduated cylinder (0.1 markings) 3. 5ml vials (0.1 and 0.3 markings) 4. 1ml plastic pipets (0.1 ml markings) 5. 1ml syringes (0.1 ml markings) 6. 1ml graduated volumetric pipets (0.01 ml markings) B. A 1ml graduated volumetric pipet is the best to use if you want 0.15 ml of reactant
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Anhydride Figure 11.3. The balanced chemical reaction of the formation of aspirin. Because the reaction is slow in pure acetic anhydride‚ the catalyst‚ commonly strong acids like phosphoric acid was used for the reaction. According to Le Chatelier’s principle‚ the presence of excess acetic anhydride forces the equilibrium towards the desired product‚ which in this case is the aspirin. In addition to this‚ the catalysts were also used to ensure that side reactions‚ which may
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Chemistry 101 Lab 7 Determination of % NaHCO3 in Alka Seltzer Tablets Names ____________________________and ___________________________ Date ____________________________ Objectives: (1) To determine the amount of NaHCO3 in Alka Seltzer tablets by observing the amount of CO2 produced from the acid-base reaction of HCO3- with acetic acid (in vinegar). (2) To study the concept of limiting reactant. Background: Alka Seltzer is an effervescent tablet that contains aspirin (acetylsalicylic
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as pharmaceutical chemistry. Synthesizing aspirin is a common example of a multistep synthesis reaction. Aspirin is typically taken as a painkiller or as a reducing-agent for fevers. In order to synthesize this product‚ the reactants salicylic acid and acetic anhydride (in excess) are used in the presence of a catalyst to create the product acetylsalicylic acid and acetic anhydride. Acetylsalicylic acid is the active pharmaceutical ingredient in aspirin and the catalyst is not consumed in the reaction
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