drug‚ via nucleophilic acid-catalyzed substitution reaction of salicyclic acid with acetic anhydride. The whole reaction is catalyzed by phosphoric acid. (The experiment involved three parts: The synthesis of aspirin‚ the isolation and purification of aspirin‚ and the estimation of the purity of the final product.) [pic] Procedure[1]: A mixture of salicylic acid (0.21g‚ 1.52 mmol) and acetic anhydride (0.52g‚ 5.1mmol‚ 0.48 ml) with one drop of concentrated phosphoric acid in a conical vial
Free Aspirin Carboxylic acid Salicylic acid
THE FRIEDEL-CRAFTS REACTION: ACETYLATION OF FERROCENE Ferrocene was acetylated in acetic anhydride and phosphoric acid. It proceeded via a Friedel-Crafts reaction without the use of organic solvents or strong Lewis acid. Operations and Observations A mixture of ferrocene (1.5 g‚ 0.008 mol)‚ acetic anhydride (5 mL) and phosphoric acid (1 mL 85%) was heated over a steam bath until all the ferrocene dissolved and the mixture darkened from orange to dark red. The mixture was then refluxed with
Premium
Previously drawn laboratory tests have been released into the patient’s chart and show a blood glucose of 110 mg/dL‚ serum total protein of 6.0 g/dL and lactate dehydrogenase (LDH) of 300 U/L. A diagnostic thoracentesis is performed‚ removing 50mL of pleural fluid. The pleural fluid will be sent for cell count‚ gram stain‚ culture‚ pH‚ glucose‚ protein and LDH. Gram stain and culture of a sputum specimen is negative for tuberculosis. If the effusion is due to the patient’s history of cirrhosis
Premium Blood Immune system Kidney
attach metal restorations and brackets used in braces to teeth. It can be supplied in bottles of powder and liquid‚ which are mixed on a glass slab or paper pad using a spatula. The liquid in glass ionomer cement contains itaconic acid‚ tartaric acid‚ maleic acid and water. The powder includes zinc oxide‚ aluminum oxide and calcium. One of the best qualities about this type of cement is that it releases Fluoride‚ which helps prevent tooth decay. It slowly is released from this powder because of its special
Premium Zinc Aluminium Oxygen
experiment was to synthesize acetanilide by the acetylation of aniline and to purify crude acetanilide product by recrystallization. The group determined water as the recrystallizing solvent. The group performed acetylation of aniline and acetic anhydride for the formation of crude acetanilide. The recrystallizing solvent dissolved the crude acetanilide and was heated in a water bath‚ after heating‚ the solution was cooled in an ice bath causing crystals to form. The percent recovery was computed
Premium Solvent Solubility Acetic acid
To get to aniline‚ tin metal acts as a reducing agent and is oxidized to SnCl4. The purification of crude aniline is done by distillation and extraction. Aniline can be converted to acetanilide by acetylation reaction using acetic anhydride with sodium acetate. This step protects the amine functional group from doing unwanted reactions during chlorosulfonation and amination steps. The chlorosulfonyl group attacks in the para position to the acetamide group‚ by electrophilic aromatic
Premium Bacteria Antibiotic resistance Penicillin
temperatures. It is also the process in which the solid to be crystallized is dissolved to either a hot solvent or a hot solvent mixture and is cooled in a solution.In this experiment‚ acetanilide‚ the crude product of acetylation of aniline and acetic anhydride‚ was used as the pure organic compound. Crude acetanilide underwent crystallization process using the preferred recrystallizing solvent‚ water. The crystallization process was when crude acetanilide was placed in hot water bath and was cooled after
Premium Solvent Solubility Oxygen
the benzene ring in salicylic acid reacts with acetic anhydride to form an ester‚ and to make aspirin. Synthesis of Acetylsalicylic Acid occurs by protonation of carbonyl (C=O) group‚ and a nucleophilic attack of OH on the acetic anhydride. The ferric chloride test and melting point were used to test the purity of the results. A hypothesized recovery rater of above 50% was expected. salicylic acid acetic anhydride Acetylsalicylic acid
Free Aspirin Acetic acid Carboxylic acid
HCl via nucleophilic substitution. Cellulose triacetate was generated by mixing cotton balls and acetic anhydride with acidic condition under heating. Materials: Styrene‚ 1 M NaOH solution‚ CaCl2(s)‚ xylene‚ t-butyl peroxybenzoate‚ methanol‚ 5% aqueous solution of 1‚ 6-hexanediamine‚ NaOH(s)‚ 5% sebacoyl chloride in hexane‚ glacial acetic acid‚ concentrated H2SO4‚ cotton balls‚ acetic anhydride‚ CH2Cl2 Procedure: For the synthesis of polystyrene‚ 10 ml styrene and 20 ml of 1 M NaOH solution was
Premium Polymer Solvent Acetic anhydride
0.947g/ml x 5ml = 4.739g Therefore moles = mass/molar mass = 4.739g/98.15g mol-1 = 0.0483 moles Mass pyrrolidine = 0.866g/mol x 4.0 ml = 3.464g Therefore moles = mass/molar mass = 3.464 / 71.11g mol-1 Addition of the acetic anhydride Enamine Acetic Anhydride Molecular formula: C10H9N Molecular formula: C4H6O3¬
Premium Distillation Laboratory glassware Solvent