History of Cystic Fibrosis “Woe to that child which when kissed on the forehead tastes salty. He is bewitched and soon must die.” This proverb‚ dating back to European folklore in the 1700’s‚ was the diagnosis for the disease recognized today as Cystic Fibrosis (CF). In that time period the disease was usually fatal and common among infants. The excessive salt in the sweat‚ just one symptom of CF‚ made the disease identifiable. However‚ since the time of European folklore‚ various renowned scientists
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Patients with Autoimmune Diseases/ Other Illness Cystic Fibrosis is a genetic disease that is passed down from both of the parents who have a copy of a defective in their DNA. There are variety of symptoms when it comes to cystic fibrosis such as: ‘Very salty-tasting skin‚ wheezing or shortness of breath‚ and male fertility ‘. There are no known cures for this genetic diseases‚ but there are treatments‚ and research that can help control this disease‚ and to possibly make a breakthrough discovery
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that encodes for a chloride channel called the cystic fibrosis transmembrane conductance regulator (CFTR). In ductal epithelial cells‚ CFTR is highly expressed and functions to transport fluid and anions into the lumen. Dysfunction of the CFTR gene leads to a decrease in luminal fluid volume and decreased pH‚ resulting in protein precipitation within the ductal lumen and loss of normal acinar cell function. Estimated gene frequency of cystic fibrosis varies in different ethnic groups with highest
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Mock Cystic Fibrosis Case Study: Part I Questions: The Meeting Consult your textbook and trustworthy Internet sites to answer the following questions: 1. Which organs are affected by cystic fibrosis? What are the disease symptoms? Organs that are affected by cystic fibrosis include the lungs‚ pancreas‚ liver‚ sweat glands‚ reproductive organs‚ nose and sinuses. The symptoms of cystic fibrosis include coughing with mucus coming up‚ wheezing‚ breathlessness‚ decrease in ability to exercise‚ lung infections
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Patient A has Cystic Fibrosis‚ which is shown by her respiratory and digestive system symptoms. Cystic Fibrosis is a genetic mutation that mutates the cystic fibrosis transmembrane conductance regulator protein(CFTR). When CFTR is working properly‚ it allows chloride to leave the cell and create a balance between the amount of chloride and water to reach homeostasis. This balance of substances is crucial to making sure that mucus is thin and slippery. Normally‚ mucus in the lungs traps germs‚ which
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On researching new developments in the treatment of cystic fibrosis‚ I came across a very interesting article: “Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect.” In the article‚ Viet et al1 reveal the potential application of the silencing of RPL12 (Ribosomal Protein L12)‚ to correct the ΔF508-CFTR biogenesis defect. As you know‚ cystic fibrosis is caused by a defect in the CF transmembrane conductance regulator (CFTR gene)‚ or more specifically‚ mutations
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were once an imminent death sentence have made outstanding medical advances. Cystic fibrosis (CF) is a genetic disorder that decreases the effectiveness of the lungs due to a mucous buildup. In the late twentieth century patients with CF could only to expect to live a few years but since 2006‚ life expectancy has risen to 36 years of age.1‚2 Cystic fibrosis is a genetic disorder that causes a mutation of the cystic fibrosis transmembrane conductance regulator (CFTR). The most common mutation is a deletion
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The Cystic Fibrosis Foundation describes Cystic Fibrosis as “a progressive‚ genetic disease that causes persistent lung infections and limits the ability to breathe over time” (www.cff.org). People with Cystic Fibrosis suffer from an increase of mucus buildup in the lungs‚ pancreas‚ and the liver; Cystic Fibrosis also affects the Nose and sinuses‚ as well as the sweat glands. The only way that CF is transmitted is by a Cystic Fibrosis positive carrier. When two positive carriers have a baby there
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The principal structure of the digestive system is an irregular tube‚ open at both ends‚ called the alimentary (al-i-MEN-tar-ee) canal or the gastrointestinal (GI) tract. In the adult‚ this hollow tube is about 9 meters (29 feet) long Think of the tube as a passageway that extends through the body like a hallway through a building. Food must be broken down or digested and then absorbed through the walls of the digestive tube before it can actually enter the body and be used by cells The teeth
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THE DIGESTIVE SYSTEM Functions of the Digestive System • Ingestion- where in food from outside of the body enters the alimentary tract through the mouth • Digestion- which could be mechanical (physical breakdown of food into smaller pieces or chemical (enzymatic action) • Absorption of digested materials into venous circulation as well as lymphatic capillaries • Provision of nutrients to the cells of the body • Elimination of undigested materials ANATOMY AND HISTOLOGY OF THE DIGESTIVE
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