unknown’s behavior in thin-layer chromatography will be compared with that of its possible component analgesics. The possible unknowns and their analgesic ingredients will be Anacin (aspirin‚ caffeine)‚ Excedrin (acetaminophen‚ caffeine‚ aspirin)‚ Motrin (ibuprofen)‚ and Tylenol (acetaminophen). Introduction Thin-layer Chromatography(TLC) was the method used to figure out and identify the drug. TLC is done on a plate that is coated with a layer of absorbent material.after the solutions have been
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development time was 50 minutes. Table 1: TLC Data for Standard Analgesics‚ Reference Mix & Unknown Components* Standard Substance | Distance Spot Travels (cm) | Distance Solvent Front Travels (cm) | Fluorescence? | I2 Staining Appearance | Acetaminophen | 48 | 150 | No | Dark Yellow | Aspirin | 86 | 150 | No | Not Significant | Caffeine | 14 | 150 | No | Not Significant | Ibuprofen | 92 | 148 | No | Not Significant | Salicylamide | 81 | 148 | Yes |
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then compared to four different components of drugs (acetaminophen‚ aspirin‚ caffeine‚ and salicylamide). Experiment Scheme1: Figure 1. Structure formulas1 Under an open flame in the hood‚ 12 capillary micropipettes were made. Two silica TLC plates were obtained‚ along with a development chamber. Each plate was prepared and labeled appropriately with a lead pencil. The first plate was spotted with acetaminophen‚ aspirin‚ caffeine‚ salicyclamide‚ and reference. The
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Acetylsalicylic Acid‚ Ibuprofen‚ Acetaminophen‚ and Caffeine based on their functional groups. The most overall polar analgesic is considered to be the analgesic that contained the most polar function groups. The amine and amide functional groups are the most polar. In this experiment‚ we found that both these functional groups are found in Caffeine. As a result‚ Caffeine was the most polar out of Acetylsalicylic Acid‚ Ibuprofen‚ Acetaminophen‚ and Caffeine. Aside from Caffeine‚ Acetaminophen has one amide functional
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increased cost‚ decreased patient satisfaction‚ and increased length of stay.21 A review of the literature was performed using the following keywords: acetaminophen‚ intravenous‚ paracetamol‚ postoperative pain‚ and analgesia. IV acetaminophen compared to oral route has shown to have a superior
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Annie’s mother asks if it is safe to give Annie children’s aspirin because she has some at home. Her husband takes it as a “blood thinner.” 1. What is your response to Annie’s mother? I would recommend using acetaminophen‚ because aspirin can make a child susceptible to Reye’s syndrome. 2. Annie will be given an antibiotic. Her mother mentions that she is allergic to penicillin. What are some checks and balances that should be in place at the physician’s office
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and tested for the purity of the drug by the melting point determination. The melting point was (135-142 C) compared to the literature melting point values for acetaminophen (169-171 C) the lower melting point show that their were still impurities in the isolated ingredient. Procedure: The acetaminophen (0.5395g) was crushed and added to a conical vial and was mixed with 2ml of methanol then shaken and let to sit till the undissolved particles settled to the bottom
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utilizing the technique of thin-layer chromatography‚ or TLC. The active ingredients of Excedrin were caffeine‚ acetaminophen‚ and aspirin with Rf values of 0.11‚ 0.38‚ and 0.61‚ respectively. The lone active ingredient of Tylenol was acetaminophen with an Rf value of 0.39. The elution sequence obtained in the experiment is as follows: ibuprofen (least polar)‚ acetylsalicylic acid‚ acetaminophen‚ and caffeine (most polar). Purpose of Experiment: The objective of this experiment is to determine the
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experiment is to investigate the composition of a simulated pharmaceutical preparation Panacetin‚ a proposed type of pain-killer. Panacetin is typically made up of sucrose‚ aspirin‚ and acetaminophen‚ but the third component in this experiment is unknown. The unknown component is suspected to be a chemical relative of acetaminophen‚ either acetanilide or phenacetin. Using techniques such as extraction‚ evaporation‚ and filtration‚ the three components will be isolated based on their solubilities and acid-base
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Introduction Chromatography is a technique used to separate a mixture into its individual components. In this experiment‚ chromatography is done by using a thin layer chromatography (TLC) plate and filter paper. The word ‘chromatography’ itself means the separation of colours. However‚ nowadays‚ both coloured and colourless compound are used in chromatography by various methods. In chromatography‚ the separation process of mixture is mainly based upon the polarity and molecular weight of sample
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