Determination of the Migration Potential in Breast and Lung Cancer Cells in presence of antimigratory therapeutic agent. Marco Brudik and Paloma Aranzazu Godinez Melgoza Medical and Pharmaceutical Biotechnology Program‚ University of Applied Sciences IMC FH Krems. Abstract. The new trends on research points to study the process of tomour-cell invasion and metastasis for developing and testing of anti-migratory agents. The present study develops a quantitative determination of the cancer cell’s
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endocrine functions Pancreas‚ gonads‚ placenta Other tissues and organs that produce hormones Adipose cells‚ thymus‚ and cells in walls of small intestine‚ stomach‚ kidneys‚ and heart Chemical Messengers Hormones: long-distance chemical signals; travel in blood or lymph Autocrines: chemicals that exert effects on same cells that secrete them Paracrines: locally acting chemicals that affect cells other than those that secrete them Autocrines and paracrines are local chemical messengers;
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Cell Size Control David A Guertin‚ Whitehead Institute for Biomedical Research‚ Cambridge‚ Massachusetts‚ USA David M Sabatini‚ Whitehead Institute for Biomedical Research‚ Cambridge‚ Massachusetts‚ USA Growth in biological systems is defined as the accumulation of mass‚ which leads to an increase in size. In this article‚ we discuss how cells‚ organs‚ and organisms normally control growth‚ and how deregulated growth can lead to a variety of pathological conditions. Introductory article Article
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The mTOR Pathway Introduction The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism‚ growth‚ proliferation and survival. Discoveries that have been made over the last decade show that the mTOR pathway is activated during various cellular processes (e.g. tumor formation‚ insulin resistance‚ adipogenesis and T-lymphocyte activation) and is deregulated in human diseases such as cancer
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instead keep track of what otherwise is going on in cell ’s environment. They may be enzymes or serve to relay the occurrence of signal reception in other ways such as by opening up ion channels. Receptor proteins are often targets for drug action. These drugs either stimulate the receptors upon binding or‚ instead‚ block the binding of receptor to normal signals. There are four principle protein targets with which drugs can interact: enzymes‚ membrane carriers‚ ion channels and receptors.
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Chapter 12 Cyclins and cyclin-dependent kinases are regulatory proteins that assist in the cell cycle. Particular protein kinases give the go-ahead signals at G1 and G2 checkpoints. These protein kinases are present at a constant concentration in the cell but are inactive unless in the presence of cyclin‚ these are cyclin dependent kinases. The activity of a cdk rises and falls with the concentration of cyclin. Cyclin levels rise during the S and G2 phases then fall abruptly in the M phase
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GDF15/MIC-1 is a product of macrophage activation‚ suggesting that it may be involved in chronic inflammatory processes (-). GDF15 is a stress-responsive member of the TGF-β superfamily and initially described as macrophage inhibitory cytokine (-). Although GDF15 has been described in many solid tumors for almost 10 years‚ the nature of its receptor is still unknown. There is some evidence of Smad signaling pathway activation‚ suggesting GDF15 may act through TGF-β receptor superfamily pathways (-)
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Chemotaxis‚ the guided movement of cells by chemical gradients created by chemoattractant proteins‚ such as chemokines and bacterial products produced at the site of inflammation‚ probably emerged early in eukaryotic evolution {Kay‚ 2008 #3289}. Neutrophils are highly mobile cells that readily undergo chemotaxis. Neutrophils can detect as low as 1/100th of a chemokine gradient. They polarize their migration towards bacterial peptides over a pool of other chemical gradients to reach sites of inflammation
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Physiology Linder Unit 1 Possible Essay Questions Chapter 1 1. Describe the concept of homeostasis. Explain how negative feedback and positive feedback loops effect the homeostatic condition. Use examples to explain your answer. Homeostasis can be described as maintaining a relatively internal environment even though the external environment is variable. Negative feedback loops effect the homeostatic condition by controlling it by bringing you back to your set point
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is mainly of protein origin‚ although there is also a varied range of steroidal hormones. (ENDOCRINE SIGNALLING: Image from University of Kent https://moodle.kent.ac.uk/external/mod/book/view.php?id=2396&chapterid=78) Pick a representative signal molecule from the pathway you have chosen and indicate its function‚ the type of cell in which it is made and the specific manner in which it acts as a signalling molecule‚ including the receptor
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