Pyrogen tests are made to “identify potential bacterial contamination of injectable products, implants, medical devices, dislysis machines, cellular therapies, recombinant proteins and IV products” (New England). Pyrogen causes an animal’s body temperature to rise such as when a person gets a fever. PETA reveals that researchers restrain rabbits and inject material into their bloodstream and then observe increases of temperature in their body. Through these tests, rabbits are prone to suffer from “fever, breathing problems, circulatory and organ failure, and even fatal shock” (PETA – “Pyrogenicity”). The American Anti-Vivisection Society claims that most data from these tests are inaccurate because age and gender differences play role in the outcome as well. One alternative that is currently being used is the Limulus amoebocyte lysate (LAL) test, which utilizes the amoebocytes from a horseshoe crab to examine the body’s responses to pyrogen (AAVS – “Testing”). It can be used instead of rabbits and other animals, allowing them to escape from such harsh and cruel testing
Pyrogen tests are made to “identify potential bacterial contamination of injectable products, implants, medical devices, dislysis machines, cellular therapies, recombinant proteins and IV products” (New England). Pyrogen causes an animal’s body temperature to rise such as when a person gets a fever. PETA reveals that researchers restrain rabbits and inject material into their bloodstream and then observe increases of temperature in their body. Through these tests, rabbits are prone to suffer from “fever, breathing problems, circulatory and organ failure, and even fatal shock” (PETA – “Pyrogenicity”). The American Anti-Vivisection Society claims that most data from these tests are inaccurate because age and gender differences play role in the outcome as well. One alternative that is currently being used is the Limulus amoebocyte lysate (LAL) test, which utilizes the amoebocytes from a horseshoe crab to examine the body’s responses to pyrogen (AAVS – “Testing”). It can be used instead of rabbits and other animals, allowing them to escape from such harsh and cruel testing