association of lipoprotein lipase gene polymorphism

Its primary feature is insufficient blood supply to the heart itself. The two major clinical forms of CHD are heart attack and angina. In a heart attack the insufficient blood flow is sudden and extreme. In angina the episodes of restricted flow are temporary and usually much less dangerous. The common underlying problem in the various forms of CHD is atherosclerosis, a complex process that affects the vessels supplying blood to the heart, the coronary arteries. In atherosclerosis, build-ups called plaques form on the inside surface of the artery. When advanced, plaques can narrow the channel through which the blood flows. Plaques can be single or multiple and can affect one or more of the heart’s three main arteries.
Coronary artery disease (CAD) is the leading cause of cardiovascular mortality worldwide, with >4.5 million deaths occurring in the developing world. Despite a recent decline in developed countries, both CAD mortality and the prevalence of CAD risk factors continue to rise rapidly in developing countries.1 CHD remains responsible for about one-third of all deaths in individuals over age 35(2,3 )
The United States government publishes very detailed figures on the incidence and prevalence of heart disease. Incidence is the number of events or new diagnoses per year. Prevalence is the number of person with the disease at any given time. Thus, there were 13.2 million Americans with heart disease in 2003 (this is prevalence - number at any given time) and there were 1.2 million Americans with a diagnosis of new or recurrent coronary heart disease in 2003 (this is the annual incidence - number of new or recurrent cases in a year).4
Age-adjusted mortality rates for coronary heart disease (CHD) have declined steadily in the United States since the 1960s5. Multiple factors likely have contributed to this decline in CHD deaths, including greater control of risk factors, resulting in declining incidence of CHD, and improved treatment6. Therefore the