Clonal Selection Theory And Its Role In Humoral Or Antibody-Mediated Immunity.

1. Explain what clonal selection theory is and its role in humoral or antibody-mediated immunity.

Clonal selection theory is a rationalization for the growth of lymphocyte specificity and diversity during immune development. This theory demonstrates how immunological memory can deliver a fast reaction when coming into contact with an antigen that has been seen for the second time. Specifically, the clonal selection theory is based on the concept that premature, undifferentiated lymphocytes in the developing fetus undergo constant genetic transformations, bringing about millions of cell types that each bring a diverse receptor with specificity. The clonal selection theory discusses two basic ideas, the first of which is that lymphocyte specificity preexists in the genetic framework before an antigen has ever arrived in the tissues. The second basic idea of the clonal selection theory is that each genetically unique lymphocyte expresses only one specificity and can respond to only one kind of antigen. The significant assortment of receptors that cells must exhibit for antigens is important in order to provide a proper immune response when the body is invaded by an infection.
During this process of clonal selection, particular stem cell lines will
Attenuated vaccines are essentially live, weaker versions of their respective virus – these milder versions are designed to mimic the virus but not cause disease. Toxoid vaccines utilize weaker versions of the toxins that certain bacteria use to attack the body in order to mimic a bacterial infection. Inactivated vaccines contain a completely inactive version of a virus, typically requiring more than one dose to produce a response in the body. This stimulates the body’s immune system to recognize the agent as a threat, destroy it, and keep record of it so that the immune system can easily recognize and destroy any of these microorganisms that it later