John F Kennedy HS
Dr. Fisher
Date: 1-14-13
Block: 3
I. Comparing DNA Sequences to Understand Evolutionary Relationships with BLAST:
III. INTRODUCTION:
NULL HYPOTHEISIS: Mental disorders are not present in animals.
HYPOTHESIS:
As much as life has evolved, the relationship between animals and humans has remained very close to each other. If animals are, evolutionally, and genetically similar to humans; can they develop the same diseases we have today? Humans today have mental disorders left and right: OCD(obsessive compulsive disorder), autism, ADD (attention deficient disorder), bipolar disorder, depression, insomnia, anxiety. If all these diseases occur in the minds of humans, can they occur in the minds of animals also? Dogs share approximately 75% of their DNA with humans; can it occur in them too?
A lacking in the protein called SAPAP3 is believed to be the cause of OCD-related symptoms in mice. If the protein SAPAP3 is found in other organisms, can they be susceptible to mental disorders similar to OCD? If the protein named SAPAP3 is found in dogs, coyotes, wolves, foxes (taxid:9608) at more than 75% identical, then these animals are vulnerable to mental disorders similar to OCD.
VI. RESULTS: QUANTITATIVE:
These are our top 5 results. The first one is nearly identical to the gene, while the bottom four are barely half similar.
The most similar protein was found in Canis lupis familiaris. It is 96% identical and 97% similar. The E value is 0.0.
The second most familiar protein was also found in Canis lupis familiaris. This genome is significantly less similar. It is 47% identical, 57% similar, and has an E Value of 0.0.
QUALITATIVE: The first result has an almost entirely identical genome as the one found to cause OCD- like symptoms in rats. This signifies, theoretically, that if there were to be an alteration or lacking in the genome in Canis lupis familiaris, the OCD-like symptoms found in