Dexmedetomidin Research Paper
Drug Formulations and Dosing Regimens
Dexmedetomidine, or 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, with molecular formula C13H16N2 [14], is the dextro-enantiomer of medetomidine, which is used as a M. A. S. Weerink et al. sedative and analgesic in veterinary medicine. Dexmedetomidine is commercially available as a water-soluble HCl salt. Vials of Dexdor_ and Precedex_ contain a concentrate of dexmedetomidine hydrochloride, equivalent to 100 lg/mL dexmedetomidine. Prior to infusion, this is diluted to 4 or 8 lg/mL. Precedex is also available in pre-diluted solutions containing the required concentrations of 4 lg/mL in sodium chloride 0.9% [2, 3]. The Dexdor summary of product characteristics advises an initial infusion rate of 0.7
Dexmedetomidine, or 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole, with molecular formula C13H16N2 [14], is the dextro-enantiomer of medetomidine, which is used as a M. A. S. Weerink et al. sedative and analgesic in veterinary medicine. Dexmedetomidine is commercially available as a water-soluble HCl salt. Vials of Dexdor_ and Precedex_ contain a concentrate of dexmedetomidine hydrochloride, equivalent to 100 lg/mL dexmedetomidine. Prior to infusion, this is diluted to 4 or 8 lg/mL. Precedex is also available in pre-diluted solutions containing the required concentrations of 4 lg/mL in sodium chloride 0.9% [2, 3]. The Dexdor summary of product characteristics advises an initial infusion rate of 0.7