The main function of insulin is to maintain blood glucose homeostasis, Insulin also controls the transport of glucose from the bloodstream into the muscle and fat cells. The effect that insulin has on cells is that when blood glucose rises the pancreas respond by secreting into the bloodstream thus Insulin moves glucose from the blood into the cells.
When insulin is not there or it doesn’t work blood glucose regulation fails and blood glucose levels rise so this shows that blood glucose is central to diabetes.
When insulin does not work or isn’t there the cells glucose levels rise and stay high that is why people with diabetes must get insulin injections if their own insulin does not work.
The types of macronutrients that the body relies on to make ATP are carbohydrates, fats, and some from proteins but protein’s main function is to be broken down into amino acids to build other proteins that humans need. People with untreated diabetes lose fat and muscle mass because glucose is what cells use for energy to do work and if glucose is not available the body starts using its fat reserves and releasing the amino acids form the muscles in order to supply the body and the brain with the energy that it needs to do the work. The body finds ways to break down fats for energy but red-blood cells and the cells of the nervous system require glucose to do work and the brain prefers glucose so amino acids are broken down when glucose does not work that is why muscle mass, fat and liver break down when response to glucose is not working properly.
Ketosis and ketoacidosis occur in people with mismanaged diabetes because if glucose continues to not work properly the body finds a way to use its fat to fuel the brain. The body adapts by combining acetyl CoA fragments derived from fatty acids to produce an alternate energy source. Ketone bodies that are normally produced and used in small quantities can efficiently provide fuel for brain cells but when ketone