Following results demonstrating increased insulin secretion in the rat islet cells, the test was repeated using pancreatic cells from cynomolgus monkeys. The monkey cells were cultured in RPMI-1640 medium and were starved in EBSS containing 2.8 mM glucose. Batches of three islets were incubated in EBSS and 16.7 mM glucose and increasing levels of dulaglutide with or without exendin. The results from the rat studies…
A certain area of interest I have that is associated with the pancreas is Diabetic ketoacidosis. Diabetic ketoacidosis is a very serious and dangerous condition that affects people who are diabetic. Diabetic ketoacidosis occurs when fat is broke down and acids called Ketones, build up in the urine and blood. When there are high levels of Ketones it becomes poisonous to the body. Though Diabetic ketoacidosis is usually seen in patients with type 1 diabetes, but it has also been seen in patients with type 2 diabetes. There are several tests that can be done to screen for Diabetic ketoacidosis, as well as treatments. Without treatment of Diabetic ketoacidosis it can be deadly (Wisse, 2013).…
PTSD and Veterans: A Conversation with Dr. Frank Ochberg documents an interview of Dr. Frank Ochberg, M.D. by broadcast journalist, Mike Walter. Dr. Ochberg is a leading psychiatrist in the treatment of posttraumatic stress disorder (PTSD) with over 30 years of field experience. He is credited with editing the foremost text for the treatment of PTSD as well as participating in the team that created the medical definition for the diagnosis. Throughout the interview, Dr. Ochberg discussed many facets of PTSD as it relates to working with military veterans as well as working with civilians. In fact, he highlighted that there is no specific differentiation between civilian PTSD and that experienced by veterans. Dr. Ochberg discussed characteristics of an effective counselor for working with those that have experienced trauma, common problems encountered, approaches to utilize, as well as the treatment of co-occurring disorders such as depression (Gift from Within, 2008).…
Read an article on a Doctor who operated on an unborn baby. Dr. Michael Harrison which referred to the unborn child a patient” It seem he was comfortable identifying the unborn as human. It appears that Dr. Michael Harrison, who called the babies he operated on a mere eight years after Roe “unborn patients,” he was comfortable speculating that the unborn child is human. Also, it ought to be clear to anybody with an ethical area that regardless of the possibility that there was vagueness on the meaning of human life, so this fair and high-minded country flavor the rights to abortion.…
At the time, diabetes was a disorder that can kill you as there was no cure for it. His interest grew when he found out that diabetes was a blood disorder, when he read in an article that diabetes happened when the sugar level in the bloodstream rose a great amount (“Frederick Banting Biography”). Banting then had an idea, an idea that changed the world. He knew from lectures that there was a substance in the pancreas that can control the sugar in the bloodstream, now known to us as insulin so he thought if he could give this substance to patients, he will be able to treat diabetes (“Sir Frederick…
El-Khatib, Russell SJ, FH. "Progress in Artificial Pancreas Development: Preventing and Treating Low Blood Glucose." American Diabetes Association. Novo Nordisk Inc., n.d. Web. 08 Sept. 2014.…
The 1920’s was a very important time in the history of Diabetes and insulin discovery and synthesis. In 1920, Frederick Banting returned from war. He was a struggling physician with a big dream = to solve the mystery that is Diabetes Mellitus. He had this idea: ‘’Ligate pancreatic ducts of dogs. Wait 6-8 weeks for degeneration. Remove the residue and extract.’’ However, he did not have the physical or financial resources to further explore the idea. (Harrison) He then returned to his alma mater, the University of Toronto, and requested the assistance of J.J.R. Macleod who was a world renowned physiologist. J.J.R Macleod…
This process allowed for the possibility of insulin removal from the body, which helped millions of people suffering from diabetes. My group chose Banting because his discovery of insulin not only helped people during 1920’s, but those of the present day as…
Genetics, viral, and chemical exposure are proposed triggers for development of type 1 diabetes (Wagner, Johnson & Hardin-Pierce, 2010) History of Juvenile Diabetes • First mention of diabetes- 1552 B.C.- Egyptian physician documents frequent urination as symptom of disease that caused emaciation, noting that ants seemed to be attracted to these individuals urine. • Centuries later “water tasters” made the diagnosis of diabetes by tasting patients urine, if it was sweet then diabetes was diagnosed. • 1889- research links removal of dogs pancreas with induction of diabetes • 1921- first extraction of isolated insulin.…
Insulin is secreted by the beta cells of the pancreas in response to high blood…
8. How would a person be affected if their pancreas produced no insulin? What disease would that person have? How could that disease be treated?…
Insulin made a huge impact on Canada. It made Canada well known and perceived as a leader in medicine. Over 1,500,00 people are affected by diabetes in Canada every year. About less than half of these are children or teenagers with Type One diabetes. Frederick Banting discovered a formula for insulin and with the help of Professor J. Macleod, Charles Best, and Dr. J B. Collip in 1921 they…
Diabetes is a silent killer! Diabetes is a lifelong progressive condition with the natural potential for the development of numerous diverse complications. These complications can arise from damage to the microvascular (small blood vessels) system and present as neuropathy, retinopathy and nephropathy or damage to the macrovascular (large blood vessels) system and present as dyslipidaemia, atherosclerosis and hypertension. Nathan & Delhanty (2005, p.42) maintains that these complications may be present at the time of diabetes mellitus diagnosis and refer to diabetes as a ‘silent killer” as diabetes can go unnoticed until a major health event occurs.…
Glucose tolerance test is used to analyse an individual’s tolerance to glucose. It is considered a valuable test as it allows health care professional to…
Attempts to distinguish T1D cases from those with T2D have also resulted in a proposed new disease classification, Latent Autoimmune Disease of Adults (LADA) (Leslie et al., 2008). However, over this past decade, the lack of firm diagnostic criteria for LADA, taken together with other notions (e.g., genetic similarity between those with T1D and the so-called LADA patients), have dramatically decreased, but not eliminated, enthusiasm for adopting this presumed “new” disease entity as a novel category for diabetes (Rolandsson, 2010). To be clear, such confusion over disease classification in settings of diabetes is not new because many terms (e.g., insulin-requiring diabetes, juvenile diabetes, insulin-dependent diabetes mellitus, etc.) have…