Effects of Skin Deterioration
Oscar M. Vistar III
Glenn John S. Guerrero
Carlo Martin P. Selera
ENGL2
Mr. Angelo O. Tubac
March 17, 2011 EFFECTS OF STRESS ON SKIN DETERIORATION
The skin provides the first line of defense between the body 's interior and harmful environmental insults by well-established physical and biochemical mechanisms. Physical protection mechanisms include the relatively impermeable barrier the skin provides. The skin can, to some extent, repel and absorb insults such as chemicals and ultraviolet light so that while the skin may be damaged, the underlying tissue is preserved. Biochemical mechanisms include the innate and acquired immune systems. The continuous mutilation, however disables the tissues to redevelop and will lead to the skin deterioration.
Deterioration of skin leads to changes in dermal thickness and elasticity due to increased crosslinking of collagen. Epidermal regeneration increases in activity while metabolism, sweat glands, and vascularization, all decrease in activity. The damage from internal and external factors is progressive and cumulative and results in the appearance of deterioration associated with aged skin. Structurally, Denda, M. affirmed that the mechanisms of skin deterioration involve a gradual and progressive process that begins from birth (314). Internal factors that contribute to skin aging include toxic metabolic byproducts, autoimmune diseases, and genetic predisposition. The consequences of internal deterioration can be observed over the entire body from the skin to the internal organs.
While the mechanisms of internal deterioration are not completely understood, somatic mutation has been shown to be a contributing factor. Under the somatic mutation theory, cells gradually lose their youthful characteristics and their capacity to divide by the accumulation of mutations (errors) in their genetic code. These mutations may be caused by free radicals or alkylating agents generated in metabolism that lead to unrepaired DNA
Glenn John S. Guerrero
Carlo Martin P. Selera
ENGL2
Mr. Angelo O. Tubac
March 17, 2011 EFFECTS OF STRESS ON SKIN DETERIORATION
The skin provides the first line of defense between the body 's interior and harmful environmental insults by well-established physical and biochemical mechanisms. Physical protection mechanisms include the relatively impermeable barrier the skin provides. The skin can, to some extent, repel and absorb insults such as chemicals and ultraviolet light so that while the skin may be damaged, the underlying tissue is preserved. Biochemical mechanisms include the innate and acquired immune systems. The continuous mutilation, however disables the tissues to redevelop and will lead to the skin deterioration.
Deterioration of skin leads to changes in dermal thickness and elasticity due to increased crosslinking of collagen. Epidermal regeneration increases in activity while metabolism, sweat glands, and vascularization, all decrease in activity. The damage from internal and external factors is progressive and cumulative and results in the appearance of deterioration associated with aged skin. Structurally, Denda, M. affirmed that the mechanisms of skin deterioration involve a gradual and progressive process that begins from birth (314). Internal factors that contribute to skin aging include toxic metabolic byproducts, autoimmune diseases, and genetic predisposition. The consequences of internal deterioration can be observed over the entire body from the skin to the internal organs.
While the mechanisms of internal deterioration are not completely understood, somatic mutation has been shown to be a contributing factor. Under the somatic mutation theory, cells gradually lose their youthful characteristics and their capacity to divide by the accumulation of mutations (errors) in their genetic code. These mutations may be caused by free radicals or alkylating agents generated in metabolism that lead to unrepaired DNA
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