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Jentadueto Research Paper

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Jentadueto Research Paper
Jentadueto (linagliptin plus metformin hydrochloride) & Sklice (ivermectin) Lotion
New Medications Approved by the FDA in 2012

Jentadueto (linagliptin plus metformin hydrochloride) In Boehringer Ingelheim (2012) Jentadueto combines two antipyperglycemic agents with complementary mechanisms of action to improve glycemic control in patients with type 2 diabetes mellitus: linagliptin, a dipeptidyl peptidase-4 (DPP-4), and metformin, a member of the biguanide class. Linagliptin is a inhibitor dipeptidyl peptidase 4 inhibitor. DPP-4 is an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP -1) and glucose-dependent. Linagliptin increases the concentrations of active incretin …show more content…
Less serious side effects may include: cough, sore throat, sinus pain, stuffy nose; upset stomach, diarrhea; or weight gain. (as cited from Drugs.com).
In Rxlist.com (2012) it is stated, lactic acidosis is a rare, but serious, complication that can occur due to metformin accumulation. The risk increases with conditions like renal impairment, sepsis, dehydration, excess alcohol intake, hepatic impairment, and acute congestive heart failure. The onset is often subtle, with symptoms such as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific abdominal distress. Laboratory abnormalities include low pH, increased anion gap, and elevated blood lactate. (as cited by Rxlist.com). …show more content…
John 's wort; topiramate (Topamax); vancomycin (Vancocin); zonisamide (Zonegran); a barbiturate such as butabarbital (Butisol), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); heart rhythm medication such as procainamide (Procan, Pronestyl, Procanbid) or quinidine (Quin-G); HIV/AIDS medication such as efavirenz (Sustiva, Atripla), etravirine (Intelence), nevirapine (Viramune), or ritonavir (Norvir, Kaletra); medicines to treat narcolepsy, such as armodafinil (Nuvigil) or modafinil (Progivil); seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), phenytoin (Dilantin), or primidone (Mysoline); or trimethoprim (Primsol, Proloprim, Bactrim, Septra, Sulfatrim, SMX-TMP, and others).
You may be more likely to have hyperglycemia (high blood sugar) if you take Jentadueto with other drugs that can raise blood sugar, such as: heart or blood pressure medications; diuretics (water pills); steroids (prednisone and others); niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others); phenothiazines
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