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The Effectiveness of Guyabano (annona muricata) leaf extract in killing dengue virus (denv)

By

ARC

CHAPTER I

THE PROBLEM AND ITS BACKGROUND

The Dengue virus is a member of the virus family Flaviviridae and is transmitted to people through the bite of the mosquitos Aedes aegypti and Aedes albopictus. Dengue virus is now believed to be the most common arthropod-borne disease in the world. Dengue is mainly found in the tropics because the mosquitoes require a warm climate. A major fear of epidemiologists is that the mosquitoes will develop resistance to cooler climates and then be able to infect people in the United
States and other temperate climates. The virus is transmitted when a mosquito of the Aedes genus bites an individual infected with dengue virus. The virus in the blood of the infected individual then infects the mosquito and travels from the mosquito's stomach to its salivary glands were the virus multiplies. The virus is then injected into another person when the mosquito injects anticoagulants that prevent blood clotting when the mosquito is feeding. The mosquito remains able to transmit dengue for its entire life.

Dengue fever, also known as breakbone fever, is an infectious tropical disease caused by the dengue virus. Symptoms include fever, headache, muscle and joint pains, and a characteristic skin rash that is similar to measles. In a small proportion of cases the disease develops into the life-threatening dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs. There was a serious outbreak in Rio de Janeiro in February 2002 affecting around one million people and killing sixteen. On March 20, 2008, the secretary of health of the state of Rio de Janeiro, Sérgio Côrtes, announced that 23,555 cases of

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