Preview

Linoleoyl Glycerol: PAF-AH Inhibitors

Satisfactory Essays
Open Document
Open Document
166 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
Linoleoyl Glycerol: PAF-AH Inhibitors
C3170

Description:
IC50: 45 µM

1-Linoleoyl glycerol is a PAF-AH inhibitor.

Platelet-activating factor (PAF), a biologically active phospholipid synthesized by a variety of stimulated cells, acts as a mediator of platelet aggregation, allergy, and inflammation. PAF is transformed to its biologically inactive lyso-PAF by the enzyme of PAF acetylhydrolase (PAF-AH). Furthermore, plasma PAF-AH has been related with atherosclerosis and may be a positive risk factor for coronary heart disease.

In vitro: 1-Linoleoyl glycerol had moderate Lp-PLA2 inhibitory activity, whereas its analog showed a very weak inhibitory activity. Their enantiomers were assessed for structural specificity against Lp-PLA2, leading to a very similar degree of inhibitory
Continue Reading
View Writing Issues

You May Also Find These Documents Helpful

  • Satisfactory Essays

    Bio/1101 Unit 1 Study Guide
    • 465 Words
    • 2 Pages

    Bio/1101 Unit 1 Study Guide

    Answer: one piece of interesting information I found in the introduction was that, low-density lipoprotein cholesterol (LDL) has been shown to be the most predictive of atherogenic susceptibility6 and has been demonstrated to exhibit oxidative susceptibility, which then relates to pathogenic oxidative processes implicated in coronary atherosclerotic plaque progression and destabilization.(page 446)…

    • 465 Words
    • 2 Pages
    Satisfactory Essays
    Read More
  • Good Essays

    Blood Chapter Checklist Bio202
    • 759 Words
    • 4 Pages

    Blood Chapter Checklist Bio202

    Platelets function in the clotting mechanism by forming a temporary plug that helps seal breaks in blood vessels…

    • 759 Words
    • 4 Pages
    Good Essays
    Read More
  • Good Essays

    WGU Biochemistry GRT1_Task 1_Lipids
    • 476 Words
    • 2 Pages

    WGU Biochemistry GRT1_Task 1_Lipids

    Biochemistry GRT1   Lipids are molecules that are not soluble in water but can be dissolved in non-polar substances such as alcohol or chloroform (Mandal, n.d.). Lipid molecules are stored in adipose, or fat tissue, and can be broken down in our bodies to form an energy called ATP. To do so, the lipid molecule is dissected into its base pieces, glycerol and fatty acids. Each of the fatty acids is then broken down into two-carbon pieces and acetyl CoA is formed from each carbon piece.…

    • 476 Words
    • 2 Pages
    Good Essays
    Read More
  • Good Essays

    unit 48 venepuncture
    • 554 Words
    • 3 Pages

    unit 48 venepuncture

    .Activity of proteins found in blood that work with platelets to help blood clot (clotting factors) some of the contribution factors of blood clotting, Includes cigarette smoking, Advanced age, Lack of physical activity, Obesity, Heart failure, Medical conditions like cancer.…

    • 554 Words
    • 3 Pages
    Good Essays
    Read More
  • Good Essays

    Serum TXB2: A Case Study
    • 90 Words
    • 1 Page

    Serum TXB2: A Case Study

    Serum TXB2was uniformly suppressed by 99% of baseline. Urinary 11-dehydro-TXB2, arachidonic acid-induced aggregation, and VerifyNow Aspirin (Accumetrics Inc., San Diego, California) showed stable, incomplete inhibition (65%, 80%, and 35%, respectively). Adenosine diphosphate- and collagen-induced aggregation was highly variable and poorly affected by aspirin, with an apparent time-dependent reversal. Inhibition of platelet cyclooxygenase activity was nonlinearly related to inhibition of platelet aggregation. Platelet function largely recovered by day 3 post-aspirin, independently of treatment duration. With any functional assay, occasionally "resistant" subjects were found to be "responders" on previous or subsequent determinations.…

    • 90 Words
    • 1 Page
    Good Essays
    Read More
  • Good Essays

    Isoproterenol (INE) And Prostaglandin Ine
    • 237 Words
    • 1 Page

    Isoproterenol (INE) And Prostaglandin Ine

    This study looks to continue the compartmentation of cAMP/cAMP-dependent protein kinase research by comparing the effects of isoproterenol (INE) and prostaglandin E1 (PGE) on the cardiomyocytes of adult male rabbit hearts in the hopes of determining the cellular or subcellular basis for the disparate effects of the two compounds. The myocytes were incubated for 15 mins at 32°C in (INE) and or (PGE) so that a comparison could be made on cAMP/cAMP-dependent protein kinase accumulation. The incubation of (INE) showcased a very dramatic and rapid collection of soluble cAMP within the cell along with an increase of particulate cAMP soluble, cAMP-dependent protein kinase and glycogen phosphorylase. However the myocytes in (INE) showed a decrease in particulate cAMP-dependent protein kinase. In comparison incubated solution of (PGE) showed an increase in soluble cAMP and soluble cAMP-dependent protein kinase while there was not a statistical significant change in particulate cAMP-dependent protein kinase and glycogen phosphorylase. These results were then tested in an incubation solution of (INE) plus (PGE) which indicated that (PGE) did not have an inhibitory effect on (INE).…

    • 237 Words
    • 1 Page
    Good Essays
    Read More
  • Good Essays

    Shima Takeo Monologue
    • 692 Words
    • 3 Pages

    Shima Takeo Monologue

    Hey, my name’s Shima Takeo. I live with my grandparents, my parents died when I was a kid. No one knows how or when, but my grandma tells me they were in an accident. I’m ten and although my parents are gone, I have no other problem in life except for one thing. I have a bit of a bully problem.…

    • 692 Words
    • 3 Pages
    Good Essays
    Read More
  • Powerful Essays

    Exp 3 Synthesis Of Aspirin Formal Lab Report
    • 2469 Words
    • 10 Pages

    Exp 3 Synthesis Of Aspirin Formal Lab Report

    Warner, T. D. & Mitchell, J. A. (2002). Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum? PNAS: Proceedings of the National Academy of Sciences of the United…

    • 2469 Words
    • 10 Pages
    Powerful Essays
    Read More
  • Better Essays

    Aspirin Synthesis
    • 2090 Words
    • 9 Pages

    Aspirin Synthesis

    Acetylsalicylic acid or more commonly known as aspirin is one of the most widely used medications to reduce fever (an antipyretic), to reduce pain (an analgesic), and to reduce swelling, soreness, and redness (an anti-inflammatory agent). It is a white, crystalline substance which melts at a temperature of about 136˚C.…

    • 2090 Words
    • 9 Pages
    Better Essays
    Read More
  • Satisfactory Essays

    Large Biological Molecules
    • 4543 Words
    • 19 Pages

    Large Biological Molecules

    In Chapter 5, the principles of chemistry covered in earlier chapters are applied to the understanding of biological polymers and lipid membranes. The emphasis is on properly linking monomers and their polymers, and on the structural and functional diversity of the different polymer types. Particular attention is given to protein structure, because this is central to understanding subsequent chapters on metabolism, molecular biology, and molecular medicine.…

    • 4543 Words
    • 19 Pages
    Satisfactory Essays
    Read More
  • Satisfactory Essays

    synthesis of aspirin
    • 328 Words
    • 2 Pages

    synthesis of aspirin

    Aspirin is most widely sold over-the-counter drug. It has the ability to reduce fever (an antipyretic), to reduce pain (an analgesic), and to reduce swelling, soreness, and redness (an anti-inflammatory agent). Much of this is believed to be due to decreased production of prostaglandins and thromboxanes. Aspirin's ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX) enzyme. Cyclooxygenase is required for prostaglandin and thromboxane synthesis. Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme.…

    • 328 Words
    • 2 Pages
    Satisfactory Essays
    Read More
  • Better Essays

    Role of Inflammation in Atherosclerosis
    • 8527 Words
    • 35 Pages

    Role of Inflammation in Atherosclerosis

    decades, and a fusion of these views has led to the concept of the atheroma as a…

    • 8527 Words
    • 35 Pages
    Better Essays
    Read More
  • Satisfactory Essays

    Expression and Purification of Human Platelet-Derived Growth Factor Beta (Pdgf-B)
    • 3122 Words
    • 13 Pages

    Expression and Purification of Human Platelet-Derived Growth Factor Beta (Pdgf-B)

    Rachel C. Hermina-Stewart* and Elsie I. Parés-Matos† *Industrial Biotechnology Program, †Department of Chemistry University of Puerto Rico-Mayagüez Campus rachel.hermina@upr.edu December 14, 2009 ABSTRACT. Platelet-Derived Growth Factor (PDGF) is one of many proteins that regulate cellular growth and division. The PDGF family consists mainly of five different isoforms called as PDGF-A, PDGF-B, PDGF-C and PDGF-D. Three active receptors for PDGF include PDGFR-α, PDGFR-β and PDGFRαβ, have been shown to be specific for the PDGF dimers. PDGF-B becomes active when dimeric and it is recognized by the three PDGF receptors. PDGF has served as a study model for the recognition of the nucleotide sequence of an aptamer. High levels of PDGF are indicative of abnormal cellular growth (conglomerates, cancer). Preliminary clinical studies show that PDGF-B levels can be monitored on the bloodstream and, in contrast from its fellow isoforms, it has the ability to activate each of the PDGF receptors (-α, -β and -αβ) shifting the balance of signaling to favor the transformation pathway. This research aims to express and purify the recombinant human PDGF-B in order to study its properties with a selected aptamer. The expression of the PDGF-B gene, cloned in the expression vector pReceiver-B04, will be controlled with rhamnose in a bacterial system suitable for the RNA T7 polymerase. The recombinant protein will be isolated, purified and characterized by SDS-PAGE and Western blot. Several chromatographic techniques including gel filtration and affinity chromatography will also be employed for the purification of the recombinant human PDGF-B.…

    • 3122 Words
    • 13 Pages
    Satisfactory Essays
    Read More
  • Good Essays

    Anti-aging ingredients
    • 1330 Words
    • 6 Pages

    Anti-aging ingredients

    granted the healthcare sector 850 billion Yuan (USD 124 billion) for reform. These factors make the…

    • 1330 Words
    • 6 Pages
    Good Essays
    Read More
  • Satisfactory Essays

    Pentraxin3 Case Study
    • 917 Words
    • 4 Pages

    Pentraxin3 Case Study

    Pentraxin3 (PTX3) is a biomarker like C-reactive protein (CRP) which belongs to Pentraxin superfamily. CRP is a short Pentraxin originated from liver, whereas PTX3 is a long Pentraxin that is highly expressed in the heart and synthesized by vascular endothelial cells and macrophages [5,6,7,8]. PTX3 has a well-established role in the innate immune response to infection [9,10]. Serum level of PTX3 has a correlation with severity of infectious disease and can be used as an independent prognostic biomarker in bacteriemia and fatal diseases [11,12]. Many studies showed that PTX3 is a widely used biomarker in clinical situations [12,13]. Recently, the role of PTX3 in cardiovascular diseases has been demonstrated in several studies [13,14]. It has been shown that the level of PTX3 elevated in the acute myocardial infarction and congestive heart failure [7,8]. The role of PTX3 as a specific biomarker for the diagnosis of PAH has also been recently demonstrated [5].…

    • 917 Words
    • 4 Pages
    Satisfactory Essays
    Read More

Related Topics