Lupus is caused by no specific gene or groups of genes.
Although it has been tied to certain genes that are not significantly strong enough to cause Lupus itself, but increase chances. Lupus has been found in certain families which concludes that it could be genetic until it is furthered looked into. There is also more evidence that makes it unpredictable if Lupus is genetic or not. "Although, when one of two identical twins has lupus, there is an increased chance that the other twin will also develop the disease (25 percent chance for identical twins; 2-3 percent chance for fraternal twins)" (Lupus.org). But also theres always the fact that certain racial groups have a stronger chance of getting Lupus in their lives, which makes researchers lean to that it can be genetic, but once again it can only be theorized until future
technology.