MRSA Synthesis

Staphylococcus aureus, otherwise known as Staph, is a bacterium that has naturally acquired resistance to many current antibiotics. Specifically, the MRSA (methicillin-resistant Staphylococcus aureus) strain has acquired resistance to methicillin. Staph frequently colonizes in human nasal passages, which serve as reservoirs for transmission. The following texts focus on Staph’s nasal colonization and mode of transmission, inspired by the research of Dr. Alexander Cole at UCF’s Burnett School of Biomedical Sciences.
Nasal Colonization of Staphylococcus aureus Ghidey, Igbinosa, and Igbinosa (2014) conducted a study comparing the rates of MRSA infections between patients who tested positive and negative for nasal colonization. The researches performed a chart review of an intensive care unit (ICU) from 2007-2010, choosing from 1203 adult patients who were screened for MRSA. For a base control, two non-colonized patients were randomly selected for every colonized patient. In the examination of future MRSA infections only lower respiratory tract (LRTIs) and bloodstream infections (BSIs) were considered, as they are the most common (Ghidey et al, 2014). Fifty-seven colonized
The AEMPs were differentiated by degrees of polymerization, ranging from 7.7 to 12. After in vitro testing of the AEMPs, Gram-positive bacteria (including Staph) were prevented greater than Gram-negative bacteria (Thoma et al, 2014). The researchers also conducted in vivo testing on cotton rats, following the model detailed by Kokia-Kun. Nasal colonization was specifically targeted in the set of trials. When compared to the control, the AEMPs highly reduced the amount of Staph cells in the subjects (Thoma et al, 2014). The research concluded that AEMPs contain antimicrobial benefits for topical Staph