Mecp2 Model Mice/Rat Model Summary And Analysis
MeCP2 model Mice/Rat (Age) Behavior Changes Molecular Changes Possible Treatments Author
MeCP2 null mice
Male-28 days,
Female-42 days Decreased lifespan, locomotion activity, heart rate, respiration pattern, social and anxiety behavior Decreased IGF-1, Akt, ERK1/2 and PSD95 levels (Whole Cell) Recombinant hIGF-1 Jorge Castro et al., (2013)
MeCP2 duplication mice
Male (10-16 weeks) Loss of episodic memory, motor learning deficits, short-term plasticity Decrease levels of GABA receptor (Hippocampus) Picrotoxin Elisa S Na et al., (2014)
MeCP2 KO mice
Male (6-8 weeks) Decreased life span, locomotion activity, brain size Decreased levels of BDNF (Cortex, Cerebellum, Hippocampus) Over expression of BDNF Qiang Chang et al., (2006)
MeCP2 model Mice/Rat
MeCP2 null mice
Male-28 days,
Female-42 days Decreased lifespan, locomotion activity, heart rate, respiration pattern, social and anxiety behavior Decreased IGF-1, Akt, ERK1/2 and PSD95 levels (Whole Cell) Recombinant hIGF-1 Jorge Castro et al., (2013)
MeCP2 duplication mice
Male (10-16 weeks) Loss of episodic memory, motor learning deficits, short-term plasticity Decrease levels of GABA receptor (Hippocampus) Picrotoxin Elisa S Na et al., (2014)
MeCP2 KO mice
Male (6-8 weeks) Decreased life span, locomotion activity, brain size Decreased levels of BDNF (Cortex, Cerebellum, Hippocampus) Over expression of BDNF Qiang Chang et al., (2006)
MeCP2 model Mice/Rat