Mr. Maslow
Bone Marrow Transplantation
(Sibling vs. non-sibling donor)
Dominika Giertlova, Petra Cerovska
Peta_cet@yaoo.com
Luba Habodaszova
BC303 Project December 10, 2011
Introduction:
We have obtained data from Antolska Hospital in Bratislava from Hematologic clinic. This clinic is one of its kind in Slovakia with highly qualified staff that treats the patients who suffer from acute Leukemia. Chemotherapy doesn’t often work and in many cases the disease comes back. The best effective treatment for diagnosed patients with this disease is to undergo the bone-marrow transplantation. “Stem cells are removed from another person, called a donor. Most times, the donor must have the same genetic makeup as the patient, so that their blood is a "match" to yours.” (Chen, 2011). This leads us to our objective for our research. It is highly preferred to find someone with a same genetic makeup, which the best chance is found in siblings of the patient, who have the highest probability to possess the same genes. But it doesn’t necessarily mean that siblings will possess this gene. If a person doesn’t have any siblings or the siblings are not a match, than the second step is taken which is the search in national or even international bone marrow registries. Our main concern is, does it matter, whether the donor is a family member or is selected from bone marrow registries? Is the chance of survival of bone marrow transplant patients higher under the circumstance of a sibling donor or not?
We have generated a random sample of 41 bone marrow transplantations in Antolska Hospital in years of 2007-2011 where the bone marrow donor was a sibling of a patient. Out of 41 procedures, 16 patients had died (6x GVHC, 5x other
(Sibling vs. non-sibling donor)
Dominika Giertlova, Petra Cerovska
Peta_cet@yaoo.com
Luba Habodaszova
BC303 Project December 10, 2011
Introduction:
We have obtained data from Antolska Hospital in Bratislava from Hematologic clinic. This clinic is one of its kind in Slovakia with highly qualified staff that treats the patients who suffer from acute Leukemia. Chemotherapy doesn’t often work and in many cases the disease comes back. The best effective treatment for diagnosed patients with this disease is to undergo the bone-marrow transplantation. “Stem cells are removed from another person, called a donor. Most times, the donor must have the same genetic makeup as the patient, so that their blood is a "match" to yours.” (Chen, 2011). This leads us to our objective for our research. It is highly preferred to find someone with a same genetic makeup, which the best chance is found in siblings of the patient, who have the highest probability to possess the same genes. But it doesn’t necessarily mean that siblings will possess this gene. If a person doesn’t have any siblings or the siblings are not a match, than the second step is taken which is the search in national or even international bone marrow registries. Our main concern is, does it matter, whether the donor is a family member or is selected from bone marrow registries? Is the chance of survival of bone marrow transplant patients higher under the circumstance of a sibling donor or not?
We have generated a random sample of 41 bone marrow transplantations in Antolska Hospital in years of 2007-2011 where the bone marrow donor was a sibling of a patient. Out of 41 procedures, 16 patients had died (6x GVHC, 5x other
References: Chen, Y. (2011). Bone Marrrow Transplant. Retrieved on December 3, 2011 from: http://www.nlm.nih.gov/medlineplus/ency/article/003009.htm