Mutation In Progeria Research Paper
Student Bio Expo 2012
Submission Template for Electronic Projects
Before filling out this form, choose the “save as” function to rename this document. Label the document as follows:
2-Letter Category Abbreviation_2-Letter School Abbreviation_LastName
For example, Lucy Jones from Eastlake High School submitting a Lab Research project would label her file:
LR_EL_Jones
2-letter category and school abbreviations can be found on the last page of this document.
Please read through this form completely before beginning.
After completion, use the “save as” function to save this document as a PDF, if possible.
Part I
Cover Sheet
Student Name:
Tisha Trongtham
School:
Ballard High School
Teacher Name:
Reimer
Grade …show more content…
Young. "The Posttranslational Processing of Prelamin A and Disease." Annual Review of Genomics and Human Genetics. 10. (2009): 153-174. Print. o This article described what gene mutation causes Progeria. It also helped me understand how a mutation in prelamin A turns it into progerin by giving a visual representation, as shown by the figure on the Cause page.
Diaz, J.. "Inside the Lives of Kids with Progeria." Abc news. 20/20, 2010. Web. 13 Jan
2012. . o Here I saw videos of real life people with Progeria, so it helped me understand the disease better. The video can be seen in 6 parts on the "Videos" page. To see the video in whole you can go to http://abcnews.go.com/2020/barbara-waltersprogeria-special-young-girls-living-progeria/story?id=11586041.
Gonzales-Suarez, Ignacio, Alena B. Redwood, and Susana Gonzalo. "Loss of A-type
Lamins and Genomic Instability." Landes Bioscience. 8.23 (2009): 3860-3865. Print. o This article talked about what lamin A does, and explained why its loss would lead to cells that age faster than normal cells.
Gordon, Leslie B., Ted W. Brown, and Francis S. Collins. "Hutchinson-Gilford Progeria
Syndrome." National Center for Biotechnology Information. (2011): n. page. Print. o This article gave an overview of Progeria …show more content…
Mestel, Rosie. "The Nation; Research Shows Drugs Could Block Early-Aging Disease;
Cancer-fighters may help correct problems linked with the rare syndrome, studies say."
LA Times [Los Angeles, California] 05 08 2005, n. pag. Print. o This article explained how Farnesyltransferase inhibitors, or FTIs, which are drugs that are used to fight cancer, can fight off Progeria as well.
Mutation causes early-aging syndrome, Vol. 163, p.260, April 26, 2003, Science News.
Print.
o This article provided information on the how the LMNA gene mutation causes
Progeria, and explained what the Lamin A protein does and what happens when it is abnormal like it is in children with Progeria.
Oshima, Junko. Personal Interview. 23 Dec 2011. o My primary source, Dr. Oshima clarified many of my questions and reviewed my research paper draft to make sure there weren’t any inaccuracies.
Reimer, Keith. Personal Communication. 2012. o My mentor for the BioExpo, he answered all my questions about the BioExpo
Submission Template for Electronic Projects
Before filling out this form, choose the “save as” function to rename this document. Label the document as follows:
2-Letter Category Abbreviation_2-Letter School Abbreviation_LastName
For example, Lucy Jones from Eastlake High School submitting a Lab Research project would label her file:
LR_EL_Jones
2-letter category and school abbreviations can be found on the last page of this document.
Please read through this form completely before beginning.
After completion, use the “save as” function to save this document as a PDF, if possible.
Part I
Cover Sheet
Student Name:
Tisha Trongtham
School:
Ballard High School
Teacher Name:
Reimer
Grade …show more content…
Young. "The Posttranslational Processing of Prelamin A and Disease." Annual Review of Genomics and Human Genetics. 10. (2009): 153-174. Print. o This article described what gene mutation causes Progeria. It also helped me understand how a mutation in prelamin A turns it into progerin by giving a visual representation, as shown by the figure on the Cause page.
Diaz, J.. "Inside the Lives of Kids with Progeria." Abc news. 20/20, 2010. Web. 13 Jan
2012. . o Here I saw videos of real life people with Progeria, so it helped me understand the disease better. The video can be seen in 6 parts on the "Videos" page. To see the video in whole you can go to http://abcnews.go.com/2020/barbara-waltersprogeria-special-young-girls-living-progeria/story?id=11586041.
Gonzales-Suarez, Ignacio, Alena B. Redwood, and Susana Gonzalo. "Loss of A-type
Lamins and Genomic Instability." Landes Bioscience. 8.23 (2009): 3860-3865. Print. o This article talked about what lamin A does, and explained why its loss would lead to cells that age faster than normal cells.
Gordon, Leslie B., Ted W. Brown, and Francis S. Collins. "Hutchinson-Gilford Progeria
Syndrome." National Center for Biotechnology Information. (2011): n. page. Print. o This article gave an overview of Progeria …show more content…
Mestel, Rosie. "The Nation; Research Shows Drugs Could Block Early-Aging Disease;
Cancer-fighters may help correct problems linked with the rare syndrome, studies say."
LA Times [Los Angeles, California] 05 08 2005, n. pag. Print. o This article explained how Farnesyltransferase inhibitors, or FTIs, which are drugs that are used to fight cancer, can fight off Progeria as well.
Mutation causes early-aging syndrome, Vol. 163, p.260, April 26, 2003, Science News.
Print.
o This article provided information on the how the LMNA gene mutation causes
Progeria, and explained what the Lamin A protein does and what happens when it is abnormal like it is in children with Progeria.
Oshima, Junko. Personal Interview. 23 Dec 2011. o My primary source, Dr. Oshima clarified many of my questions and reviewed my research paper draft to make sure there weren’t any inaccuracies.
Reimer, Keith. Personal Communication. 2012. o My mentor for the BioExpo, he answered all my questions about the BioExpo